Recombinant Rat CCL2 (C-6His)是来自大鼠的重组CCL2蛋白，在人源细胞中表达，带有C端6×His标签。该蛋白即单核细胞趋化蛋白1（MCP-1），是β（C-C）亚族趋化因子成员，对单核细胞和嗜碱性粒细胞有趋化作用，结合CCR2受体后具有多种促肿瘤作用，还可作为乳腺癌和前列腺癌诊断生物标志物，能诱导人单核细胞释放花生四烯酸。
Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 化学结构 CAS号：N/A
Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 3D分子结构 CAS号：N/A
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the cognate receptor CCR2, and together this signaling pair has been shown to have multiple pro-tumorigenic roles, from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression. CCL2 is found in the circulation, where it has been suggested as a diagnostic biomarker of breast cancer and prostate cancer. CCL2 can also induce arachidonic acid release in human monocytes, which has been shown to be involved in adhesion and induction of the chemotactic response, in a pertussis-toxinsensitive manner.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 技术信息
CAS号
N/A
分子量
14.9 KDa
SMILES Code
NONE
别名
重组大鼠CCL2蛋白(HEK293, C-6His)
;Recombinant Rat CCL2 (C-6His); C-C motif chemokine 2; Ccl2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Small-inducible cytokine A2; Scya2
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His)
|Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His)
| 重组大鼠CCL2蛋白(HEK293, C-6His)
| Recombinant Rat CCL2 (C-6His)
| C-C motif chemokine 2
| Ccl2
| Monocyte chemoattractant protein 1
| Monocyte chemotactic protein 1
| MCP-1
| Small-inducible cytokine A2
| Scya2
| N/A
| Chemokine & Receptors
| Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 纯度/质量文件
| Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 生物活性
| Rat CCL2 (C-6His)/大鼠CCL2蛋白(HEK293, C-6His) 技术信息
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