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/ Proflavine Hemisulfate/硫酸原黄素

Proflavine Hemisulfate/硫酸原黄素 {[allProObj[0].p_purity_real_show]}

货号：A656336 同义名： 原黄素半硫酸盐 / 3,6-Diaminoacridine hemisulfate; Proflavin hemisulfate

Proflavine hemisulfate is an acridine-derived fluorescent contrast and disinfectant agent potentially used for cellular imaging and antiseptic purposes.

Proflavine Hemisulfate/硫酸原黄素 化学结构 CAS号：1811-28-5
Proflavine Hemisulfate/硫酸原黄素 化学结构
CAS号：1811-28-5
Proflavine Hemisulfate/硫酸原黄素 3D分子结构
CAS号：1811-28-5
Proflavine Hemisulfate/硫酸原黄素 化学结构 CAS号：1811-28-5
Proflavine Hemisulfate/硫酸原黄素 3D分子结构 CAS号：1811-28-5
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Proflavine Hemisulfate/硫酸原黄素 纯度/质量文件 产品仅供科研

货号：A656336 标准纯度： {[allProObj[0].p_purity_real_show]}
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Proflavine Hemisulfate/硫酸原黄素 生物活性

描述 Proflavine hemisulfate is an Acridine derivative, which is a slow-acting disinfectant with bacteriostatic action against many Gram-positive bacteria but less effective against Gram-negative organisms[2]. Moreover, the bacteriostatic agent, proflavine, preferentially blocked a subset of inward rectifier K+ (Kir) channels[3]. Mutants resistant to 1. 0 mM PF (Proflavine) were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells[4]. In comparing proflavine-light and placebo-light treatment, 0. 1% proflavine administration twice daily for 5 days had a significant effect in suppressing herpetic eye disease, but 0. 05% proflavine was less effective[5]. Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens[6].

Proflavine Hemisulfate/硫酸原黄素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02494310 Neoplasia of the Uterine Cervi... 展开 >>x Cancer Prevention Cervical Intraepithelial Neoplasia 收起 << Not Applicable Completed - -
NCT02420665 Cervical Cancer Early Phase 1 Active, not recruiting September 2025 United States, Texas ... 展开 >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT02335372 Cervical Cancer Not Applicable Active, not recruiting June 2020 Brazil ... 展开 >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 收起 <<

Proflavine Hemisulfate/硫酸原黄素 参考文献

[1]Prieto SP, Powless AJ, et al. Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology. PLoS One. 2015 May 11;10(5):e0125598.

[2]Pridgeon JW, Klesius PH, Yildirim-Aksoy M. Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. Vaccine. 2013 Apr 26;31(18):2222-30. doi: 10.1016/j.vaccine.2013.03.004. Epub 2013 Mar 13. PMID: 23499519.

[3]Inanobe A, Itamochi H, Kurachi Y. Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction. Mol Pharmacol. 2018 Jun;93(6):592-600. doi: 10.1124/mol.117.111377. Epub 2018 Apr 12. PMID: 29650538.

[4]McKellar RC, McKenzie CN, Kushner KJ. Correlation of resistance to proflavine and penicillin in Escherichia coli. Antimicrob Agents Chemother. 1976 Oct;10(4):765-7. doi: 10.1128/AAC.10.4.765. PMID: 791110; PMCID: PMC429826.

[5]Lanier JD, Whitcher JP, Dawson CR, Oh JO. Proflavine and light in the treatment of experimental herpetic ocular infections. Antimicrob Agents Chemother. 1974 Nov;6(5):613-9. doi: 10.1128/AAC.6.5.613. PMID: 15825315; PMCID: PMC444702.

[6]Prieto SP, Powless AJ, Boice JW, Sharma SG, Muldoon TJ. Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology. PLoS One. 2015 May 11;10(5):e0125598. doi: 10.1371/journal.pone.0125598. PMID: 25962131; PMCID: PMC4427403.

Proflavine Hemisulfate/硫酸原黄素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.27mL

3.25mL

1.63mL

32.54mL

6.51mL

3.25mL

Proflavine Hemisulfate/硫酸原黄素 技术信息

CAS号1811-28-5
分子式C13H13N3O4S
分子量 307.33
SMILES Code NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.O=S(O)(O)=O
MDL No. MFCD00149650
别名 原黄素半硫酸盐 ;3,6-Diaminoacridine hemisulfate; Proflavin hemisulfate; Hemisulfate, Proflavine; Acridine, 3,6-Diamino; 3,6 Diamino Acridine; 3,6-Acridinediamine, sulfate (2:1); EINECS 217-320-3; Proflavine hemisulfate dihydrate; Proflavine hemisulphate
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place,Sealed in dry,2-8°C
溶解方案

H2O: 5 mg/mL(16.27 mM)

Tags: Proflavine hemisulfate | 1811-28-5 | Proflavin hemisulfate | 3,6-Diaminoacridine hemisulfate | Anti-infection | Membrane Transporter/Ion Channel | Autophagy | Bacterial | Potassium Channel | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Proflavine Hemisulfate/硫酸原黄素 纯度/质量文件 | Proflavine Hemisulfate/硫酸原黄素 生物活性 | Proflavine Hemisulfate/硫酸原黄素 临床数据 | Proflavine Hemisulfate/硫酸原黄素 参考文献 | Proflavine Hemisulfate/硫酸原黄素 实验方案 | Proflavine Hemisulfate/硫酸原黄素 技术信息

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