Procyanidin B1, a natrual product isolated and prufied from the fruits of Vitis vinifera L., inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with IC50 of 29μM and 15μM, respectively.
Procyanidin B1/原花青素B1 细胞实验
Cell Line
Concentration
Treated Time
Description
References
BEnd.3 cells
394 µM
48 hours
No significant toxicity
Phytother Res. 2024 Dec;38(12):5583-5597
GL261 cells
394 µM
48 hours
Inhibited GL261 cell proliferation
Phytother Res. 2024 Dec;38(12):5583-5597
PC12 cells
2.5 µM and 5 µM
24 hours
To evaluate the protective effect of Procyanidin B1 on MPP+-induced PC12 cell damage. Results showed that 5 µM Procyanidin B1 significantly improved cell viability, reduced LDH leakage, decreased ROS and MDA content, increased antioxidant enzyme activity, and upregulated the expression of Nrf2/ARE pathway-related proteins.
Molecules. 2022 Aug 6;27(15):5007
U251 cells
394 µM
48 hours
Inhibited U251 cell proliferation and downregulated NRF2 expression
Phytother Res. 2024 Dec;38(12):5583-5597
Procyanidin B1/原花青素B1 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6N mice
Intracranial glioblastoma orthotopic model
Oral administration
15 mg/kg
Once daily for 44 days
Inhibited tumor growth and prolonged survival
Phytother Res. 2024 Dec;38(12):5583-5597
C57BL/6J mice
High-fat-diet-induced diabetic model
Oral
150 mg/kg, 250 mg/kg
Once daily for 8 weeks
Procyanidin B1 and coumaric acid alleviated high-fat-diet-induced hyperlipidemia by activating PPARα expression, regulating hepatic lipid metabolism and gut microbiota. Results showed that supplementation with PB and CA significantly decreased serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL-C) levels, and increased high-density lipoprotein (HDL-C) levels. Additionally, PB and CA improved gut microbiota dysbiosis, reducing the relative abundance of Ruminococcaceae and increasing the relative abundance of Lactobacillus, Desulfovibrio, and Akkermansia.
Foods. 2024 Jun 12;13(12):1843
Zebrafish
Parkinson's disease model
Water immersion
25 µM
4 days
To evaluate the protective effect of Procyanidin B1 on the zebrafish Parkinson's disease model. Results showed that 25 μM Procyanidin B1 significantly improved motor ability, reduced dopaminergic neuron damage, decreased MDA content, increased antioxidant enzyme activity, and upregulated the expression of Nrf2/ARE pathway-related genes.
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