Probucol | DH-581 | Virus Protease Inhibitor | AmBeed-信号通路专用抑制剂

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Probucol/普罗布考 {[allProObj[0].p_purity_real_show]}

货号：A177844 同义名： DH-581; Lorelco

Probucol是一种合成抗氧化剂，通过增加低密度脂蛋白（LDL）分解速率来降低血液中的胆固醇水平。

Probucol/普罗布考化学结构
CAS号：23288-49-5

Probucol/普罗布考 3D分子结构
CAS号：23288-49-5

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Probucol/普罗布考纯度/质量文件产品仅供科研

货号：A177844 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]; • Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]; • Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]; • Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]; 更多 >

Probucol/普罗布考生物活性

描述	Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Probucol/普罗布考临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03753555	Stroke, Ischemic ... 展开 >> Atherosclerosis, Cerebral 收起 <<	Phase 4	Not yet recruiting	November 30, 2021	-
NCT00598533	Coronary Heart Disease	Phase 4	Completed	-	Germany ... 展开 >> Medizinische Klinik, Klinikum rechts der Isar Muenchen, Germany, 81675 Deutsches Herzzentrum Muenchen Munich, Germany, 80636 收起 <<
NCT00276133	Chronic Nephropathy	Phase 4	Completed	-	Japan ... 展开 >> Yokohama City University Center Hospital Yokohama, Kanagawa, Japan, 232-0024 收起 <<

Probucol/普罗布考参考文献

[1]Xiao X, Hou H, et al. Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation. Oxid Med Cell Longev. 2017;2017:1284804.

[2]Wei SM, Huang YM, et al. Probucol Reduces Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats. Oxid Med Cell Longev. 2017;2017:5424097.

Probucol/普罗布考实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.67mL

1.93mL

0.97mL

19.35mL

3.87mL

1.93mL

Probucol/普罗布考技术信息

CAS号	23288-49-5
分子式	C₃₁H₄₈O₂S₂
分子量	516.84
SMILES Code	CC(SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C
MDL No.	MFCD00079281

别名	DH-581; Lorelco; Hoechst Brand of Probucol; Superlipid; Lurselle; Lesterol; Bisphenabid; Biphenabid; NSC 652160; NSC 86225
运输	蓝冰
InChI Key	FYPMFJGVHOHGLL-UHFFFAOYSA-N
Pubchem ID	4912

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(203.16 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 9 mg/mL clear

PO 0.5% CMC-Na 39 mg/mL suspension

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03753555	Stroke, Ischemic ... 展开 >> Atherosclerosis, Cerebral 收起 <<	Phase 4	Not yet recruiting	November 30, 2021	-
NCT00598533	Coronary Heart Disease	Phase 4	Completed	-	Germany ... 展开 >> Medizinische Klinik, Klinikum rechts der Isar Muenchen, Germany, 81675 Deutsches Herzzentrum Muenchen Munich, Germany, 80636 收起 <<
NCT00276133	Chronic Nephropathy	Phase 4	Completed	-	Japan ... 展开 >> Yokohama City University Center Hospital Yokohama, Kanagawa, Japan, 232-0024 收起 <<
NCT01013532	Brain Ischemia ... 展开 >> Intracranial Hemorrhages 收起 <<	Phase 4	Unknown	December 2016	-
NCT03430284	Diabetes Mellitus, Type 2	Phase 4	Recruiting	December 31, 2020	China, Shandong ... 展开 >> Shandong Provincial Hospital Not yet recruiting Jinan, Shandong, China, 250021 Contact: Shanshan Shao +8653168776094 shaoshanshan11@126.com Shandong Provincial Hospital Recruiting Jinan, Shandong, China 收起 <<
NCT02483169	Brain Ischemia ... 展开 >> Intracranial Hemorrhages 收起 <<	Phase 4	Unknown	December 2016	-
NCT03026465	Coronary Artery Disease	Phase 4	Recruiting	April 2018	Spain ... 展开 >> Complejo Hospitalario Universitario de Vigo Not yet recruiting Vigo, Pontevedra, Spain Hospital Clinico San Carlos Recruiting Madrid, Spain, 28040 Contact: Nieves Gonzalo, MD, PhD +34913303283 nieves_gonzalo@yahoo.es Contact: Javier Escaned, MD, PhD javier.escaned@salud.madrid.org Principal Investigator: Nieves Gonzalo, MD, PhD Sub-Investigator: Carlos Macaya, MD, PhD Sub-Investigator: Javier Escaned, MD, PhD Sub-Investigator: Antonio Fernández Ortiz, MD, PhD Sub-Investigator: Pilar Jiménez, MD, PhD Sub-Investigator: Luis Nombela, MD, PhD Sub-Investigator: María del Trigo, MD, PhD Sub-Investigator: Iván Núñez, MD, PhD Sub-Investigator: Pablo Salinas, MD, PhD Hospital Universitario de La Princesa Not yet recruiting Madrid, Spain 收起 <<
NCT00823849	Type 2 Diabetes Mellitus ... 展开 >> Arteriosclerosis Obliterans 收起 <<	Phase 4	Completed	-	China ... 展开 >> Peking University First Hospital Beijing, China 收起 <<
NCT01031667	Therapy	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Severance Hospital, Yonsei University Health System Seoul, Korea, Republic of 收起 <<
NCT00823875	Atherosclerosis Cerebral Infar... 展开 >>ction 收起 <<	Phase 4	Completed	-	China ... 展开 >> First Affliate Hospital of Beijing University Beijing, China 收起 <<
NCT02196805	Chinese Healthy Volunteers	Not Applicable	Completed	-	China ... 展开 >> Clinical Pharmacology Research Center Peking Union Medical College Hospital Beijing, China 收起 <<
NCT00549978	Healthy	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Clinical Trial Center, Seoul National University Hospital Seoul, Korea, Republic of, 110-744 收起 <<
NCT02730390	-		Completed	-	-
NCT00655330	Type 2 Diabetes Mellitus ... 展开 >> Nephropathy 收起 <<	Not Applicable	Unknown	May 2017	China, Guangdong ... 展开 >> Guangdong General Hospital Guangzhou, Guangdong, China, 510080 收起 <<
NCT01291641	Hyperlipidemias	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Dong-A Medical Center Seogu, Busan, Korea, Republic of, 602-715 Samsung Medical Center Seoul, Gangnam-Gu, Korea, Republic of, 135-710 Seoul National University Bundang Hospital Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Boramae Medical Center Dongjak-Gu, Seoul, Korea, Republic of, 156-707 Seoul National University Hospital Jongno-gu, Seoul, Korea, Republic of, 110-744 收起 <<
NCT00426348	Glomerulonephritis ... 展开 >> IGA Nephropathy 收起 <<	Phase 4	Completed	-	China, Guangdong ... 展开 >> Guangdong General Hospital Guangzhou, Guangdong, China, 510080 收起 <<
NCT01000467	Healthy	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Seoul national univeristy Seoul, Korea, Republic of 收起 <<
NCT02098460	Severe Hypercholesterolemia	Phase 4	Unknown	April 2017	China ... 展开 >> Anzhen hospital Recruiting Beijing, China Contact: Jie Lin, Dr 00861064412431 Principal Investigator: Jie Lin, Dr 收起 <<
NCT01252056	Diabetic Nephropathy	Phase 4	Completed	-	China, Beijing ... 展开 >> Beijing Universuty First Hospital Beijng, Beijing, China 收起 <<
NCT01726816	Diabetic Nephropathy	Phase 2	Completed	-	Korea, Republic of ... 展开 >> The Catholic university of Korea, Bucheon St. Mary's Hospital Bucheon, Korea, Republic of Kyungpook National University DaeGu, Korea, Republic of Yeungnam University Medical Center DaeGu, Korea, Republic of Gil Hospital Incheon, Korea, Republic of Inha University Hospital InCheon, Korea, Republic of Chonbuk national University Hospital JeonJu, Korea, Republic of Eulji Hospital Seoul, Korea, Republic of Kangbuk Samsung Hospital Seoul, Korea, Republic of Kangnam Sacred Hospital Seoul, Korea, Republic of Korea University Guro Hospital Seoul, Korea, Republic of Kyunghee Univ Hospital at Kangdong Seoul, Korea, Republic of Samsumg Medical Center Seoul, Korea, Republic of Severance Hospital Seoul, Korea, Republic of Seoul National University Bundang Hospital SungNam, Korea, Republic of St. Vincent Hospital Suwon, Korea, Republic of UIJEONGBU ST. MARY's HOSPITAL Uijeongbu, Korea, Republic of 收起 <<
NCT01349010	Hyperlipidemia	Phase 3	Completed	-	China, Hunan ... 展开 >> The Sencond Xiangya Hospital of Central South University Changsha, Hunan, China, 410011 收起 <<
NCT02707458	Dementia of the Alzheimer Type... 展开 >> Age-related Cognitive Decline Mild Cognitive Impairment Due to Alzheimer Disease 收起 <<	Phase 1 Phase 2	Completed	-	Canada, Quebec ... 展开 >> Douglas Hospital Research Centre Montreal, Quebec, Canada, H4H1R3 收起 <<
NCT01590901	Healthy	Phase 1	Completed	-	China ... 展开 >> Clinical Pharmacology Research Center, Peking Union Medical College Hospital Beijing, China 收起 <<
NCT01142284	Peripheral Artery Disease	Phase 2	Unknown	-	Korea, Republic of ... 展开 >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: SeungWhan Lee, MD.PhD. 82-2-3010-3170 seungwlee@amc.seoul.kr Principal Investigator: SeungWhan Lee, MD.PhD. 收起 <<

Probucol/普罗布考 {[allProObj[0].p_purity_real_show]}

Probucol/普罗布考纯度/质量文件产品仅供科研

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Probucol/普罗布考质控信息

Probucol/普罗布考生物活性

Probucol/普罗布考临床研究

Probucol/普罗布考参考文献

Probucol/普罗布考实验方案

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Probucol/普罗布考 {[allProObj[0].p_purity_real_show]}

Probucol/普罗布考 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Probucol/普罗布考 质控信息

Probucol/普罗布考 生物活性

Probucol/普罗布考 临床研究

Probucol/普罗布考 参考文献

Probucol/普罗布考 实验方案

Probucol/普罗布考 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

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Probucol/普罗布考纯度/质量文件产品仅供科研

Probucol/普罗布考质控信息

Probucol/普罗布考生物活性

Probucol/普罗布考临床研究

Probucol/普罗布考参考文献

Probucol/普罗布考实验方案

Probucol/普罗布考技术信息