Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
Probucol/普罗布考 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Mesenchymal stem cells (MSCs)
50, 100, 150 µM
12 hours
To investigate the protective effect of probucol on MSCs under oxidative stress, results showed that probucol reversed H2O2-induced damage, improved cell viability, and reduced ROS production.
Stem Cell Res Ther. 2020 Jul 21;11(1):302
MC3T3-E1 cells
0.1 µM
24 hours, 48 hours, 72 hours
To evaluate the effect of Probucol on the viability and function of MC3T3-E1 cells, the results showed that Probucol at 10 µM significantly improved cell viability and reduced H2O2-induced oxidative stress.
Mol Med. 2022 Jun 28;28(1):75
Probucol/普罗布考 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
New Zealand White rabbits
Balloon-injured carotid artery model in cholesterol-fed rabbits
Oral
1%
Continued for 5 weeks
To evaluate the effects of probucol on neointimal thickening and macrophage accumulation after balloon injury. Results showed that probucol significantly reduced serum cholesterol levels, inhibited neointimal thickening, and reduced macrophage accumulation.
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11312-6
SD rats
Bilateral ovariectomy (OVX)-induced osteoporosis model
Oral gavage
1 mg/kg and 3.5 mg/kg
Once daily for 12 weeks
To evaluate the therapeutic effect of Probucol on osteoporosis in OVX rats, the results showed that Probucol significantly improved bone density and trabecular structure, and reduced oxidative stress-mediated abnormal bone metabolism.
Mol Med. 2022 Jun 28;28(1):75
Mice
Pdss2 mutant mice
Oral
1% w/w
From weaning through at least 6 months of age or for 3 weeks prior to typical nephritis onset
Probucol significantly ameliorated focal segmental glomerulopathy-like kidney disease in Pdss2 mutant animals, restored CoQ9 content in mutant kidney, and mitigated transcriptional alterations across many intermediary metabolic domains, including peroxisome proliferator-activated receptor (PPAR) pathway signaling.
EMBO Mol Med. 2011 Jul;3(7):410-27
Sprague-Dawley rats
Diabetic mellitus-induced erectile dysfunction (DMED) model
Oral
500 mg/kg/day
Once daily for 4 weeks
To evaluate the effect of probucol combined with MSCs in the treatment of diabetic erectile dysfunction, results showed that the combination therapy significantly improved erectile function, reduced fibrosis, and increased endothelial function.
Korea, Republic of
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Dong-A Medical Center
Seogu, Busan, Korea, Republic of, 602-715
Samsung Medical Center
Seoul, Gangnam-Gu, Korea, Republic of, 135-710
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707
Boramae Medical Center
Dongjak-Gu, Seoul, Korea, Republic of, 156-707
Seoul National University Hospital
Jongno-gu, Seoul, Korea, Republic of, 110-744 收起 <<
Korea, Republic of
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The Catholic university of Korea, Bucheon St. Mary's Hospital
Bucheon, Korea, Republic of
Kyungpook National University
DaeGu, Korea, Republic of
Yeungnam University Medical Center
DaeGu, Korea, Republic of
Gil Hospital
Incheon, Korea, Republic of
Inha University Hospital
InCheon, Korea, Republic of
Chonbuk national University Hospital
JeonJu, Korea, Republic of
Eulji Hospital
Seoul, Korea, Republic of
Kangbuk Samsung Hospital
Seoul, Korea, Republic of
Kangnam Sacred Hospital
Seoul, Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Kyunghee Univ Hospital at Kangdong
Seoul, Korea, Republic of
Samsumg Medical Center
Seoul, Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of
Seoul National University Bundang Hospital
SungNam, Korea, Republic of
St. Vincent Hospital
Suwon, Korea, Republic of
UIJEONGBU ST. MARY's HOSPITAL
Uijeongbu, Korea, Republic of 收起 <<
Korea, Republic of
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Asan Medical Center
Recruiting
Seoul, Korea, Republic of
Contact: SeungWhan Lee, MD.PhD. 82-2-3010-3170 seungwlee@amc.seoul.kr
Principal Investigator: SeungWhan Lee, MD.PhD. 收起 <<
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