Investigated the effect of Pristane on TremL4 expression, showing that Pristane dose-dependently enhanced TremL4 staining
Elife. 2022 Oct 20;11:e76205
Pristane 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
SJL/J mice
Intraperitoneal injection
0.5 mL
Single injection, observed for 16 weeks
To study the impact of Xist RNP on autoimmune pathology in the pristane-induced SLE model. Results showed that pristane injection coupled with tgXist expression in males led to higher incidence and severity of glomerulonephritis, hepatic lipogranulomas, and pulmonary hemorrhage, reflecting disease damage observed in severe SLE patients.
Cell. 2024 Feb 1;187(3):733-749. e16
BALB/c mice
Pristane-induced SLE model
Intraperitoneal injection
0.5 mL
Single injection, lasted for 24 weeks
The pristane-induced SLE model simulates human SLE manifestations, including proteinuria, serositis, and glomerulonephritis. Dietary OLA supplementation improved kidney damage and endothelial dysfunction.
Antioxidants (Basel). 2023 Jun 19;12(6):1303
C57BL/6 mice
Pristane-induced lupus nephritis model
Intraperitoneal injection
0.5 mL
Single injection
To induce lupus nephritis model, results showed that pristane injection led to increased proteinuria, renal function impairment, and renal pathological changes.
Front Immunol. 2021 Jul 5;12:683249.
C57BL/6 mice
Pristane-induced DAH model
Intraperitoneal injection
0.5 mL
Single injection, observed until day 14
To evaluate the therapeutic potential of miR-146a in DAH. Results showed that intra-pulmonary miR-146a delivery could suppress DAH by reducing TRAF6, IL-8, NETs and apoptosis expression.
J Biomed Sci. 2022 Aug 26;29(1):62
Mice
CD38-deficient mice
Intraperitoneal injection
0.5 mL
Single dose, observed for 2 weeks
To study pristane-induced lupus-like disease, finding that CD38-deficient mice showed milder inflammatory responses compared to wild-type mice
Front Immunol. 2022 Oct 24;13:1013236
Mice (C57BL/6 background)
Pristane-induced lupus model
Intraperitoneal injection
0.5 mL
Single injection, observed for 10 months
To evaluate the impact of OGG1 deficiency on lupus-like inflammatory responses, showing enhanced inflammation and skin pathology in Ogg1?/? mice
Front Immunol. 2020 Sep 24;11:554725
Mice
Pristane-induced diffuse alveolar hemorrhage model
Intraperitoneal injection
0.5 mL
Single injection, observed for 7 days
To evaluate the role of ER stress in pristane-induced lung injury. Results showed increased expression of ER stress markers (e.g., Chop and Bip) in the lungs of pristane-treated mice, correlating with neutrophil infiltration.
Front Immunol. 2022 Feb 3;13:790043
Mice
Pristane-induced lupus model
Intraperitoneal injection
0.5 mL
Single injection, observed for 6 months
Study the role of autophagy in the maintenance of autoreactive memory B cells and lupus development
Front Immunol. 2021 Jul 16;12:701066
C57BL/6 mice
Pristane-induced lupus model
Intraperitoneal injection
0.5 mL
Single injection, observed for 14 days
Studied the effect of Pristane on monocyte differentiation and DAH, showing that Pristane treatment increased circulating Ly6C?CD138+ monocytes, associated with DAH susceptibility
Elife. 2022 Oct 20;11:e76205
CBA/Igb mice
Pristane-induced arthritis model
Intraperitoneal injection
0.5 mL
Two injections, 50 days apart
To investigate whether Pristane-induced arthritis is dependent on CD4+ T cells. Results showed that Pristane-induced arthritis depends on the presence of CD4+ T cells.
Immunology. 1997 Jan;90(1):81-6
C57BL/6 mice
Pristane-induced acute SLE-like lung inflammation model
Intraperitoneal injection
0.5 mL
Single injection, observed at 3, 7, and 14 days
To evaluate the effect of Pristane on lung inflammation, results showed that Pristane treatment led to reduced miR-125a expression, enhanced IL-16 expression, and increased neutrophil infiltration in the lungs.
JCI Insight. 2018 Aug 9;3(15):e120798
BALB/c mice
Pristane-induced lupus model
Intraperitoneal injection
0.5 mL
Single injection
Induce lupus-like disease and evaluate cognitive impairment and features of neuropsychiatric lupus
Int J Mol Sci. 2024 Dec 5;25(23):13080
BALB/c mice
Pristane-induced lupus model
Intraperitoneal injection
0.5 mL
Single injection, observed at 1, 2, 4, or 8 months
To investigate whether the pristane-induced lupus model is suitable for neuropsychiatric lupus (NPSLE) studies. Results showed that PIL mice exhibited olfactory dysfunction, anxiety- and depression-like behavior, and pathological changes in the brain.
Behav Brain Funct. 2023 Feb 10;19(1):3
BALB/c mice
Pristane induced lupus mouse model
Intraperitoneal injection
0.5 mL
Single injection, lasting for 4 months
To study the effects of Pristane-induced lupus mouse model on neuroinflammation and behavioral deficits. Results showed that Pristane-induced lupus mice exhibited olfactory dysfunction, anxiety- and depression-like behaviors, as well as neuroinflammation and brain pathological changes.
Behav Brain Funct. 2023 Jun 15;19(1):11
C57BL/6 mice
Pristane-induced SLE model
Intraperitoneal injection
0.5mL
Single injection, sacrificed on Day 7
To evaluate the effect of GSK-J4 on ISG expression in the Pristane-induced SLE model, results showed that GSK-J4 reduced ISG expression in peritoneal monocytes
Arthritis Rheumatol. 2024 Mar;76(3):396-410
Dark Agouti rats
Pristane-induced arthritis model
Intradermal injection
100 µL
Single injection, monitored for 15 weeks
To investigate the effect of pre-existing periodontitis on the development and immune/inflammatory response of pristane-induced arthritis. Results showed that pre-existing periodontitis did not affect the development or severity of arthritis.
J Transl Med. 2016 Nov 3;14(1):311
Rats
Pristane-induced arthritis model
Intradermal injection
150 μl
Single injection, monitored for 90 days or longer
To study the chronic course, histopathological features, and genetic influences of pristane-induced arthritis. Results showed arthritis onset within 2-3 weeks post-injection, characterized by chronic, relapsing, and progressive joint inflammation with bone and cartilage erosions.
Am J Pathol. 1996 Nov;149(5):1675-83
Sprague-Dawley rats
Pristane-induced arthritis model
Intradermal injection
300 µL
Administered on day 0 and day 4
To induce arthritis and assess disease severity, results showed successful establishment of pristane-induced arthritis model for evaluating therapeutic effects
NPJ Regen Med. 2022 Feb 2;7(1):13
C57BL/6 mice
Pristane-induced lupus model
Intraperitoneal injection
500 µL
Single injection, lasting 8 months
To study the impact of cGAS deficiency on lupus pathology. Results showed that Cgas-/- mice exhibited more severe pulmonary hemorrhage, autoantibody production, and inflammatory cell infiltration, indicating cGAS deficiency exacerbates lupus pathology.
Front Immunol. 2022 Dec 16;13:1010764
C57BL/6 mice
Pristane-induced lupus model
Intraperitoneal injection
500 µL
Single injection, lasted for 6 months
To investigate the effect of iron deficiency on the disease progression of pristane-induced lupus, results showed that iron deficiency improved renal damage, reduced autoantibody production, and promoted Treg cell expansion.
Front Immunol. 2022 Feb 28;13:799331
Mice
Pristane-induced lupus model
Intraperitoneal injection
500 µL
Single injection, duration of 6 months
To investigate the role of type III interferons in pristane-induced lupus model. Results showed improved survival rates, reduced lipogranuloma formation, and decreased early-phase autoantibody titers in Ifnlr1?/? mice.
Int J Mol Sci. 2021 Oct 29;22(21):11747
Mice
Systemic lupus erythematosus model
Intraperitoneal injection
500 μl
Single injection
Induction of systemic lupus erythematosus symptoms, including proteinuria, elevated levels of antinuclear antibodies (ANAs) and anti-dsDNA antibodies, and kidney inflammation and immune complex deposition. AIM2 deficiency ameliorated these symptoms.
Signal Transduct Target Ther. 2021 Sep 14;6(1):341
Mice
Pristane-induced lupus nephritis model
Intraperitoneal injection
500 μl
Single injection, observation period up to 9 months
To evaluate the effect of Pristane on inflammation and immune responses in NLRP12-deficient mice, results showed NLRP12-deficient mice exhibited more severe inflammation and immune responses
J Clin Invest. 2023 Feb 1;133(3):e157272
Mice
Pristane-induced lupus model
Intraperitoneal injection
500 μl
Single injection
To investigate the role of AIM2 in lupus development, results showed that AIM2 deficiency ameliorated lupus symptoms
Clin Transl Med. 2022 Mar;12(3):e781
C57BL/6 mice
Pristane-induced lupus nephritis model
Intraperitoneal injection
500 μl
Single injection, lasting for 4 months
To study the Pristane-induced lupus nephritis model for evaluating the therapeutic effect of exosomes derived from BMMSCs on lupus nephritis.
Stem Cell Res Ther. 2022 Sep 24;13(1):484
BALB/c mice
Pristane-induced lupus nephritis model
Intraperitoneal injection
500 μL
Single injection
To evaluate the effects of Pristane on lupus nephritis, results showed that Pristane-induced LN mice exhibited severe renal damage, including glomerulonephritis and tubular inflammation.
Int J Mol Sci. 2019 Jul 15;20(14):3466
Mice
Dnase1–/–Dnase1L3–/– double-knockout mice
Intraperitoneal injection
500 μL
Single dose
Accelerated disease phenotype, resulting in 50% mortality in untreated DKO mice, while LBme-treated DKO mice showed reduced mortality to 15%
JCI Insight. 2024 Jun 18;9(14):e177003
Pristane 动物研究
Animal study
系统性红斑狼疮[1]
动物：Balb/c 小鼠，雌性，8周。
给药：0.5 mL , 腹腔注射，单次给药。
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