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/ Prednisolone Acetate/醋酸泼尼松龙

Prednisolone Acetate/醋酸泼尼松龙 {[allProObj[0].p_purity_real_show]}

货号：A386186 同义名： Prednisolone 21-acetate

Prednisolone Acetate是 泼尼松 的醋酸盐形式，作为一种合成类固醇，具有免疫抑制和抗炎作用。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Prednisolone Acetate/醋酸泼尼松龙 化学结构 CAS号：52-21-1
Prednisolone Acetate/醋酸泼尼松龙 化学结构
CAS号：52-21-1
Prednisolone Acetate/醋酸泼尼松龙 3D分子结构
CAS号：52-21-1
Prednisolone Acetate/醋酸泼尼松龙 化学结构 CAS号：52-21-1
Prednisolone Acetate/醋酸泼尼松龙 3D分子结构 CAS号：52-21-1
规格 价格 会员价 库存 数量
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Prednisolone Acetate/醋酸泼尼松龙 纯度/质量文件 产品仅供科研

货号：A386186 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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Prednisolone Acetate/醋酸泼尼松龙 生物活性

描述 Prednisolone 21-acetate is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

Prednisolone Acetate/醋酸泼尼松龙 细胞实验

Cell Line
Concentration Treated Time Description References
Fast-twitch muscle fibre bundles 250 nM 10-15 minutes Investigate the effects of PDNA on maximum isometric force in fast-twitch fibres, showing that 250 nM PDNA had no significant effect on Po. J Physiol. 2013 Oct 15;591(20):5171-85.
Slow-twitch muscle fibre bundles 250 nM 10-15 minutes Investigate the effects of PDNA on maximum isometric force in slow-twitch fibres, showing that 250 nM PDNA significantly increased Po within 10 minutes. J Physiol. 2013 Oct 15;591(20):5171-85.

Prednisolone Acetate/醋酸泼尼松龙 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Glucocorticoid-induced osteoporosis model Subcutaneous implantation 5 mg/kg 60 days To investigate the effect of prednisolone acetate on bone formation in mice. Results showed that prednisolone acetate significantly decreased trabecular bone volume and cortical bone thickness, and reduced bone mineral density (BMD). Biochem Pharmacol. 2017 Jul 15;136:109-121.
ICR mice Ocular alkali burn model Eye drops 1% Twice daily for 5 days Used as a positive control to compare the therapeutic effects of RCI001 in the ocular alkali burn model. Results showed that RCI001 restored corneal epithelial integrity more rapidly than corticosteroid treatment. Front Immunol. 2022 Mar 24;13:850287
C57BL/6 mice LPS-induced keratitis model Topical administration 1% solution Four times daily for 3 days To evaluate the anti-inflammatory effect of prednisolone acetate in a mouse model of LPS-induced corneal inflammation. Results showed that prednisolone acetate reduced LPS-induced corneal inflammation, decreased the number of neutrophils and macrophages, and reduced the expression of TNF-α, IL-6, and IL-1β. Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6589-99
Rabbits Rabbit eye model Topical eye drops 1% 4 doses per day for 10 days To evaluate the effect of prednisolone acetate on treating vaccinia virus keratitis. Results showed that prednisolone acetate interfered with viral clearance, and ocular disease rebounded after treatment cessation. J Infect Dis. 2011 Mar 1;203(5):683-90
Sprague-Dawley rats Corneal alkali injury model Topical administration 1% Twice daily for two weeks Prednisolone acetate significantly attenuated corneal opacity and fibrosis in alkali-burned cornea but failed to decrease the population of α-SMA-positive corneal myofibroblasts. Int J Mol Sci. 2020 Apr 23;21(8):2990
Mice Inflammation-induced corneal neovascularization model Topical 1% eye drops Three times daily for 10 days To evaluate the effect of anti-inflammatory therapy on inflammation-induced lymphangiogenesis. Results showed a 68% reduction in the lymphvascularized area in FVB/NCrl mice and a 34% reduction in Balb/cAnNCrl mice. Am J Pathol. 2010 Jul;177(1):501-10

Prednisolone Acetate/醋酸泼尼松龙 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01685983 Prostate Cancer Phase 2 Completed - Korea, Republic of ... 展开 >> Busan, Korea, Republic of Cheongju-Si, Korea, Republic of Seongnam-Si, Gyeonggi-Do, Korea, Republic of Seoul, Korea, Republic of Taiwan Kaohsiung, Taiwan Taichung City, Taiwan Taichung, Taiwan Taipei, Taiwan Taoyuan County, Taiwan 收起 <<
NCT01685983 - Completed - -
NCT02002078 Esophageal Diseases Phase 4 Completed - -

Prednisolone Acetate/醋酸泼尼松龙 参考文献

[1]Garg P, Tuteja N, Qayum S. To Study the Efficacy of Difluprednate Ophthalmic Emulsion and Prednisolone Acetate Ophthalmic Suspension on Post-operative Inflammation in Cataract Surgery. J Clin Diagn Res. 2016 Dec;10(12):NC05-NC08.

[2]Jeng KW, Fine HF, et al. Incidence of steroid-induced ocular hypertension after vitreoretinal surgery with difluprednate versus prednisolone acetate. Retina. 2014 Oct;34(10):1990-6.

Prednisolone Acetate/醋酸泼尼松龙 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.85mL

4.97mL

2.48mL

Prednisolone Acetate/醋酸泼尼松龙 技术信息

CAS号52-21-1
分子式C23H30O6
分子量 402.48
SMILES Code O=C1C=C[C@]2(C)[C@@]3([H])C(O)C[C@]4(C)[C@](C(COC(C)=O)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
MDL No. MFCD00037710
别名 Prednisolone 21-acetate
运输蓝冰
InChI Key LRJOMUJRLNCICJ-JZYPGELDSA-N
Pubchem ID 5834
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C
溶解方案

DMSO: 50 mg/mL(124.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Prednisolone | 52-21-1 | Prednisolone 21-acetate | Glucocorticoid Receptor | Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Glucocorticoid Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Prednisolone Acetate/醋酸泼尼松龙 纯度/质量文件 | Prednisolone Acetate/醋酸泼尼松龙 生物活性 | Prednisolone Acetate/醋酸泼尼松龙 临床数据 | Prednisolone Acetate/醋酸泼尼松龙 参考文献 | Prednisolone Acetate/醋酸泼尼松龙 实验方案 | Prednisolone Acetate/醋酸泼尼松龙 技术信息

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