To evaluate the effect of Pogostone on STAT3 activation and inflammatory mediator expression. Results showed that Pogostone significantly inhibited STAT3 activation and nuclear translocation, and reduced the production of inflammatory mediators.
J Adv Res. 2025 May;71:429-440
S. typhimurium HYM2
32 µg/mL to 256 µg/mL
18–24 hours
Pogostone showed significant synergistic effect with colistin against MCR-1-positive strains
Molecules. 2022 Apr 28;27(9):2819
K. pneumoniae ZJ02
32 µg/mL to 256 µg/mL
18–24 hours
Pogostone showed significant synergistic effect with colistin against MCR-1-positive strains
Molecules. 2022 Apr 28;27(9):2819
E. coli ZJ487
32 µg/mL to 256 µg/mL
18–24 hours
Pogostone showed significant synergistic effect with colistin against MCR-1-positive strains
Molecules. 2022 Apr 28;27(9):2819
E. coli BL21 (DE3) (pET28a-mcr-1)
32 µg/mL to 256 µg/mL
18–24 hours
Pogostone showed significant synergistic effect with colistin against MCR-1-positive strains
Molecules. 2022 Apr 28;27(9):2819
Lymphocytes
20-80 µM
48 hours
Evaluate the effect of PO on lymphocyte cell cycle, results showed PO inhibited lymphocyte proliferation via G0/G1 phase arrest
Mol Med Rep. 2017 Oct;16(4):4511-4520
Lymphocytes
5-80 µM
48 hours
Evaluate the effect of PO on lymphocyte viability, results showed low concentrations of PO had no toxicity on lymphocytes
Mol Med Rep. 2017 Oct;16(4):4511-4520
Lymphocytes
20-80 µM
72 hours
Evaluate the effect of PO on ConA-stimulated lymphocyte proliferation, results showed PO inhibited lymphocyte proliferation
Mol Med Rep. 2017 Oct;16(4):4511-4520
Pogostone/广藿香酮 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Balb/c mice
DNCB-induced DTH model
Oral
10, 20, 40 mg/kg
Once per day for 7 consecutive days
Evaluate the immunosuppressive effect of PO on DTH response, results showed PO ameliorated tissue hypertrophy and inflammatory cell infiltration
Mol Med Rep. 2017 Oct;16(4):4511-4520
Sprague-Dawley rats
Indomethacin-induced gastric ulcer model
Oral
10, 20, 40 mg/kg
7 consecutive days
To evaluate the gastroprotective effect and underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats. Results showed that pogostone pretreatment significantly reduced gastric ulcer area, improved gastric mucosal damage, enhanced antioxidant enzyme activities, decreased lipid peroxidation levels, increased PGE2 content, upregulated COX-1 and COX-2 expressions, and exhibited antiapoptotic effects.
Exp Biol Med (Maywood). 2016 Jan;241(2):193-204
C57BL/6J mice
Healthy mouse model
Gavage
20 mg/kg
15 consecutive days
To investigate the prebiotic effect of Pogostone through the modulation of gut microbiota (GM). Results showed that Pogostone improved the gut epithelial barrier, modulated the GM composition, increased the abundance of beneficial bacteria, reduced pathogenic bacteria, and activated SCFAs receptors.
Front Pharmacol. 2019 Oct 17;10:1229
Sprague-Dawley rats
TNBS-induced experimental colitis model
Enema
20, 40, and 80 mg/kg
Once daily for 7 days
PO significantly reduced the disease activity index (DAI) of TNBS-induced colitis by inhibiting the infiltration of Th1 and Th17 cells, ameliorating inflammatory features including ulceration, adhesion, and edema. Additionally, PO inhibited the activity of myeloperoxidase (MPO) and the secretion of inflammatory cytokines (IFN-γ, IL-12p70, IL-17A, IL-10).
Front Pharmacol. 2017 Nov 17;8:829
BALB/c mice
LL37-induced rosacea-like mouse model
Topical administration
350 μM
Once daily for 7 days
To evaluate the therapeutic effect of Pogostone on rosacea-like skin inflammation. Results showed that Pogostone significantly alleviated skin inflammation symptoms, inhibited STAT3 activation and IL-36γ expression.
J Adv Res. 2025 May;71:429-440
BALB/c mice
Systemic infection model
Intraperitoneal injection
50 mg/kg
Single dose, observed for 72 hours
Combination therapy with pogostone and colistin significantly increased the survival rate of mice to 80.0% and reduced bacterial burdens in the liver, spleen, and kidney
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