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/ Piperacillin sodium/哌拉西林钠

Piperacillin sodium/哌拉西林钠 {[allProObj[0].p_purity_real_show]}

货号：A881033 同义名： Sodium piperacillin; Piperacillin (sodium salt)

Piperacillin sodium是一种广谱β-内酰胺抗生素，属于氨苄青霉素类。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Piperacillin sodium/哌拉西林钠 化学结构 CAS号：59703-84-3
Piperacillin sodium/哌拉西林钠 化学结构
CAS号：59703-84-3
Piperacillin sodium/哌拉西林钠 3D分子结构
CAS号：59703-84-3
Piperacillin sodium/哌拉西林钠 化学结构 CAS号：59703-84-3
Piperacillin sodium/哌拉西林钠 3D分子结构 CAS号：59703-84-3
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Piperacillin sodium/哌拉西林钠 纯度/质量文件 产品仅供科研

货号：A881033 标准纯度： {[allProObj[0].p_purity_real_show]}
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Piperacillin sodium/哌拉西林钠 生物活性

描述 Piperacillin sodium is a broad-spectrum β-lactam antibiotic[2]. At a concentration of 0. 1 mg/mL, piperacillin inhibited all streptococci except enterococci. At 25 mg/mL, piperacillin inhibited 95% of Pseudomonas aeruginosa and 78% of Bacteroides fragilis. Synergistic activity of piperacillin was demonstrated when it was combined with amikacin, gentamicin, and cefazolin against P. aeruginosa and members of the Enterobacteriaceae[3]. In addition, piperacillin causes mitochondrial dysfunction in neuron cells as shown by the reduction of mitochondrial respiration, membrane potential, and ATP production[4].

Piperacillin sodium/哌拉西林钠 细胞实验

Cell Line
Concentration Treated Time Description References
Imi-1 enzyme 7.8 to 72 nM Inhibition of Imi-1 enzyme activity Antimicrob Agents Chemother. 2004 Dec;48(12):4589-96.
High-level CTX-M-15-producing E. coli >256 μg/mL 24 hours Evaluate the antibacterial activity of Piperacillin alone against high-level CTX-M-15-producing E. coli, MIC value was >256 μg/ml Antimicrob Agents Chemother. 2016 Mar 25;60(4):2075-80.
Moderate-level CTX-M-15-producing E. coli >256 μg/mL 24 hours Evaluate the antibacterial activity of Piperacillin alone against moderate-level CTX-M-15-producing E. coli, MIC value was >256 μg/ml Antimicrob Agents Chemother. 2016 Mar 25;60(4):2075-80.
Low-level CTX-M-15-producing E. coli 128 μg/mL 24 hours Evaluate the antibacterial activity of Piperacillin alone against low-level CTX-M-15-producing E. coli, MIC value was 128 μg/ml Antimicrob Agents Chemother. 2016 Mar 25;60(4):2075-80.
Pseudomonas aeruginosa ATCC27853 8 mg/L 24 hours Evaluate the bactericidal effect of Piperacillin alone on susceptible strains, showing significant reduction in bacterial counts Antimicrob Agents Chemother. 1994 Oct;38(10):2351-6.
Staphylococcus aureus 7176 128 mg/L 24 hours Evaluate the effect of Piperacillin alone on resistant strains, showing transient bacterial killing followed by regrowth Antimicrob Agents Chemother. 1994 Oct;38(10):2351-6.
Escherichia coli J53.2-TEM-3 128 mg/L 24 hours Evaluate the effect of Piperacillin alone on resistant strains, showing transient bacterial killing followed by regrowth Antimicrob Agents Chemother. 1994 Oct;38(10):2351-6.
Escherichia coli J53 4 mg/L 24 hours Evaluate the bactericidal effect of Piperacillin alone on susceptible strains, showing significant reduction in bacterial counts Antimicrob Agents Chemother. 1994 Oct;38(10):2351-6.
Bacteroides spp. 2-512 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Pseudomonas aeruginosa 4-512 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Klebsiella pneumoniae 1-512 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Escherichia coli 1-512 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Enterococcus faecalis >512 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Staphylococcus aureus 16-128 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Branhamella catarrhalis 0.5-16 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.
Haemophilus influenzae 0.5-128 μg/ml Compared the in vitro activities of Piperacillin and Ticarcillin, Piperacillin was more effective against β-lactamase-negative strains. Antimicrob Agents Chemother. 1989 Aug;33(8):1268-74.

Piperacillin sodium/哌拉西林钠 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00435305 - Terminated(difficulties by enr... 展开 >>olling patients fundings consumed, no staff could be recruited and payed to continue enrolling patients,) 收起 << November 2007 Germany ... 展开 >> Universitäsklinikum Tübingen, Klinik für Anästhesiologie und Intensivmedizin Tübingen, Germany, 72076 收起 <<
NCT01667094 Cystic Fibrosis Phase 4 Active, not recruiting July 2017 Australia, Victoria ... 展开 >> The Alfred Hospital Melbourne, Victoria, Australia, 3181 收起 <<
NCT01066013 Infections Not Applicable Unknown June 2010 -

Piperacillin sodium/哌拉西林钠 参考文献

[1]Williamson R, Hakenbeck R, et al. In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

[2]Leung E, Venkatesan N, Ly SC, Scheetz MH. Physical compatibility of vancomycin and piperacillin sodium-tazobactam at concentrations typically used during prolonged infusions. Am J Health Syst Pharm. 2013 Jul 1;70(13):1163-6. doi: 10.2146/ajhp120409. PMID: 23784164.

[3]Fu KP, Neu HC. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978 Mar;13(3):358-67. doi: 10.1128/AAC.13.3.358. PMID: 122519; PMCID: PMC352246.

[4]Jiang S, Li T, Zhou X, Qin W, Wang Z, Liao Y. Antibiotic drug piperacillin induces neuron cell death through mitochondrial dysfunction and oxidative damage. Can J Physiol Pharmacol. 2018 Jun;96(6):562-568. doi: 10.1139/cjpp-2016-0679. Epub 2017 Jul 31. PMID: 28759731.

Piperacillin sodium/哌拉西林钠 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.85mL

0.37mL

0.19mL

9.27mL

1.85mL

0.93mL

18.53mL

3.71mL

1.85mL

Piperacillin sodium/哌拉西林钠 技术信息

CAS号59703-84-3
分子式C23H26N5NaO7S
分子量 539.54
SMILES Code O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)[O-].[Na+]
MDL No. MFCD00917471
别名 Sodium piperacillin; Piperacillin (sodium salt); Piperacillin curasan; Piperacillin; Pipera-hameln; Hexal Brand of Piperacillin Sodium; Fresenius Brand of Piperacillin Sodium; curasan Brand of Piperacillin Sodium; Piperacillin (sodium); Pipracil; PIPERACILLIN SODIUM SALT; T-1220; CL 227,193
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 105 mg/mL(194.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(185.34 mM)

Tags: Piperacillin sodium | Sodium piperacillin;Piperacillin (sodium salt);Piperacillin curasan;Piperacillin;Pipera-hameln;Hexal Brand of Piperacillin Sodium;Fresenius Brand of Piperacillin Sodium;curasan Brand of Piperacillin Sodium;Piperacillin (sodium);Pipracil;PIPERACILLIN SODIUM SALT;T-1220;CL 227,193 | Penicillin | Antibacterial | AmBeed-信号通路专用抑制剂 | Piperacillin sodium/哌拉西林钠 纯度/质量文件 | Piperacillin sodium/哌拉西林钠 生物活性 | Piperacillin sodium/哌拉西林钠 临床数据 | Piperacillin sodium/哌拉西林钠 参考文献 | Piperacillin sodium/哌拉西林钠 实验方案 | Piperacillin sodium/哌拉西林钠 技术信息

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