Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease. Target: ACE Perindopril is a long-acting ACE inhibitor[3]. It is indicated for the treatment of essential hypertension either alone or in combination with other antihypertensives, especially thiazide diuretics[4]. Perindopril is effective and safe for blood pressure control with a dose-dependent effect. Perindopril in combination with amlodipine significantly reduced total and cardiovascular mortality as compared to atenolol/diuretic in large-scale clinical trials of hypertensive patients[5]. Perindopril 4 to 8 mg once daily significantly reduces supine systolic blood pressure (SBP) and diastolic blood pressure (DBP) from baseline values in hypertensive patients. Perindopril 4 to 8 mg once daily significantly decreased carotid-femoral aortic pulse wave velocity (PWV), improved arterial compliance, reduced left ventricular mass index and, in patients with recent cerebral ischaemia and/or stroke, preserved cerebral blood flow despite significantly reducing SBP and DBP[6].
Perindopril Erbumine/培哚普利叔丁胺 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Chang cells
0.156, 0.313, 0.625, 1.25, 2.5, 5.0, 10.0 µg/mL
24 hours
To evaluate cytotoxicity, results showed that perindopril, PMAE, and Mg/Al-layered double hydroxide had no toxic effects on Chang cells at concentrations up to 10.0 µg/mL.
Int J Nanomedicine. 2012;7:4251-62
Perindopril Erbumine/培哚普利叔丁胺 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Wistar rats
Aluminum chloride (AlCl3) induced Alzheimer's disease model
Oral
0.5 mg/kg/day and 1 mg/kg/day
Once daily for consecutive 60 days
To evaluate the protective effect of perindopril and azilsartan as monotherapy or in combination on aluminum chloride (AlCl3) induced neurobehavioral and pathological changes. Results showed that oral administration of either azilsartan and perindopril alone or in combined for 60 days have shown improvement of cognitive function, significant reduction in the hippocampal levels of Aβ-42, Acetylcholinesterase, Malondialdehyde (MDA), Tumor necrosis factor (TNF-α) and reserved most of histopathological changes in dentate gyrus (DG) and Cornu Ammonis-3 (CA3) that mediated by Alcl3.
Saudi Pharm J. 2020 May;28(5):574-581
New Zealand rabbits
Ischemic heart failure model
Oral
0.66 mg/kg/day
Once daily for 4 weeks
To evaluate the effects of perindopril on ventricular remodeling and myocardial fibrosis in rabbits with ischemic heart failure. Results showed that perindopril significantly improved cardiac function and reduced myocardial fibrosis.
Front Physiol. 2019 Mar 22;10:267
Balb/c male mice
DSS-induced colitis model
Oral gavage
1 mg/kg/day
Once daily for one week
Perindopril alone or in combination with ambrosin ameliorated DSS-induced colitis in mice by modulating TLR4/NF-κB signaling and SIRT1/PPAR-γ levels, reducing oxidative stress and inflammatory responses, and improving histopathological and electron microscopic changes in colonic tissues.
Pharmaceuticals (Basel). 2022 May 13;15(5):600
Mice
DENA-induced hepatocellular carcinoma model
Oral
1 mg/kg/day
Once daily for four weeks
Perindopril, whether used alone or in combination with sorafenib, decreased liver enzymes and preserved liver architecture. The study revealed that perindopril significantly enhanced the antineoplastic, antiangiogenic, and anti-metastatic effects of sorafenib. This effect was associated with the downregulation of the leptin/Wnt/β-catenin pathway, overexpression of ALDH1, and downregulation of EpCAM.
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