PFM01
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货号：A1365292
PFM01是一种MRE11内切酶抑制剂，可以防止双链断裂重修复过程的切割，增强非同源末端连接（NHEJ）并减少同源重组。
PFM01 化学结构
CAS号：1558598-41-6
PFM01 3D分子结构
CAS号：1558598-41-6
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PFM01 纯度/质量文件 产品仅供科研
货号：A1365292
标准纯度：
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PFM01 质控信息
PFM01 生物活性
| 描述 |
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by non-homologous end-joining (NHEJ) versus homologous recombination (HR). PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells. PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells. PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells. PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[2]. |
PFM01 细胞实验
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Cell Line
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Concentration |
Treated Time |
Description |
References |
| 1BR3 hTERT cells |
100 µM |
30 minutes |
Inhibits MRE11 endonuclease activity, promotes NHEJ repair |
Mol Cell. 2014 Jan 9;53(1):7-18 |
| A549 cells |
100 µM |
30 minutes |
Inhibits MRE11 endonuclease activity, reduces chromatin-bound RPA levels, and decreases IR-induced RAD51 foci formation |
Mol Cell. 2014 Jan 9;53(1):7-18 |
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PFM01 参考文献
[1]Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Epub 2013 Dec 5. Erratum in: Mol Cell. 2014 Jan 23;53(2):361. PMID: 24316220; PMCID: PMC3909494.
[2]Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18
PFM01 实验方案
| 计算器 |
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| 存储液制备 |
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1mg |
5mg |
10mg |
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1 mM
5 mM
10 mM
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3.41mL
0.68mL
0.34mL
|
17.04mL
3.41mL
1.70mL
|
34.08mL
6.82mL
3.41mL
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PFM01 技术信息
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