There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Oxytetracycline hydrochloride, a member of the tetracycline class of antibiotics, effectively inhibits both Gram-negative and Gram-positive bacteria. It functions as a protein synthesis inhibitor by preventing the binding of aminoacyl-tRNA to the mRNA-ribosome complex and also exhibits anti-HSV-1 (Herpes Simplex Virus-1) activity[1].[2].[3].
体内研究
The pharmacological impact of oxytetracycline varies across species. When administered at a therapeutic dose of 82.8 mg/kg of body weight to 1% body weight per day for 10 days, it influences various biological parameters differently among fish species. In Morone chrysops x M. saxatilis, it increases relative liver weight. In Ictalurus punctatus, it enhances the enzymatic activity of CYP3A4, whereas in Oreochromis niloticus, it increases protein expression of CYP3A4 but depletes hepatic CYP3A4[1].
Regulatory limits for oxytetracycline residue include 100 μg/kg in muscle and milk, 200 μg/kg in eggs, 300 μg/kg in liver, and 600 μg/kg in kidney tissues. In aquaculture, oxytetracycline is typically administered via medicated feed at concentrations ranging from 35 to 75 mg active ingredient per kg of biomass per day for durations of 7 to 14 days[1].
体外研究
Oxytetracycline is also a key member of the bacterial aromatic polyketide family, a class of structurally diverse natural products. It is synthesized via a type II polyketide synthase process, which constructs a poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units. This backbone is then modified by various enzymes such as cyclases, oxygenases, transferases, and other tailoring enzymes to achieve its final structure[2].
Oxytetracycline HCI/盐酸氧四环素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Melissococcus plutonius 2019BC1
32 μg/mL
72 hours
To determine the minimum inhibitory concentration (MIC) of Oxytetracycline against Melissococcus plutonius 2019BC1. Results showed the strain was resistant to Oxytetracycline with an MIC of 32 μg/mL.
Sci Rep. 2022 Apr 7;12(1):5906
Oxytetracycline HCI/盐酸氧四环素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Galleria mellonella (greater wax moth larvae)
Greater wax moth larvae model
Oral (via food)
1 mg/100 g food, 10 mg/100 g food, 100 mg/100 g food, 400 mg/100 g food
Continuous feeding over five generations
To investigate the impact of antibiotics on the gut microbiome of greater wax moth larvae, finding that high doses of oxytetracycline lead to early larval mortality, while low doses increase larval size.
BMC Microbiol. 2018 Dec 29;18(1):228
Honey bee larvae (Apis mellifera)
In vitro reared honey bee larvae infection model
Oral administration via larval diet
1, 10, 100 and 1000 μg/mL
Daily administration for 4-5 days
To evaluate the therapeutic effect of Oxytetracycline on honey bee larvae infected with Melissococcus plutonius. Results showed 100 μg/mL OTC effectively prevented clinical signs of EFB disease, but 1000 μg/mL was toxic to larvae.
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