There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Oxyclozanide (OXZ) is a salicylanilide anthelmintic drug that mainly acts by uncoupling oxidative phosphorylation in flukes. Goats treated with LVM (levamisole)-OXZ combination at the recommended dose for sheep may result in a reduced efficacy, because of under-dosing, which may increase the risk of drug resistance in parasites[1]. Oxyclozanide in combination with colistin increased the activity of colistin against Col-S and Col-R A. baumannii, P. aeruginosa and K. pneumoniae. Time-kill curves showed synergistic activity between oxyclozanide and colistin against these bacterial isolates. Moreover, Col-R (colistin-resistant) A. baumannii, P. aeruginosa and K. pneumoniae in the presence of oxyclozanide presented greater permeability and disruption of their cell wall than Col-S (colistin against colistin-susceptible) strains, without modification of their outer membrane protein profile[2]. The LD50 of oxyclozanide was ~3,707 mg/kg body weight, and the lowest observed adverse effect level of oxyclozanide was at a dose of 74 mg/kg in rats[3]. Oxyclozanide demonstrated in-vitro antibacterial activity against meticillin-resistant S. pseudintermedius[4].
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