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Obefazimod

货号:A722436 同义名: Abx464; SPL-464

Obefazimod是一种 HIV 复制抑制剂,有望用于治疗 HIV 感染。

Obefazimod 化学结构 CAS号:1258453-75-6
Obefazimod 化学结构
CAS号:1258453-75-6
Obefazimod 3D分子结构
CAS号:1258453-75-6
Obefazimod 化学结构 CAS号:1258453-75-6
Obefazimod 3D分子结构 CAS号:1258453-75-6
规格 价格 库存 数量
50μL*10mM(DMSO) ¥99随货¥69 咨询
100μL*10mM(DMSO) ¥139随货¥99 咨询
250μL*10mM(DMSO) ¥259随货¥189 咨询
500μL*10mM(DMSO) ¥369随货¥259 咨询
10mM*1mL(DMSO) ¥516 咨询
1mg ¥329 咨询
5mg ¥469 咨询
10mg ¥778 咨询
25mg ¥1555 咨询
50mg ¥2489 咨询
100mg ¥3640 咨询
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Obefazimod 纯度/质量文件 产品仅供科研

货号:A722436 标准纯度:
批次查询: 批次纯度:

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Obefazimod 生物活性

描述 Obefazimod effectively suppresses HIV-1 production in cells infected with PBMC and macrophages. It exhibits robust inhibitory action against all tested HIV-1 subtypes, including B, C, and recombinant forms. Obefazimod also strongly prevents the replication of viral strains that possess mutations granting resistance to various therapeutic drugs in vitro. Unlike the antiviral medication 3TC, which shows limited activity against K65R and M184V mutant strains, Obefazimod successfully inhibits both. In an effort to extend the understanding of Obefazimod's impact on HIV-1 replication in other primary cells, treatments range from 0.01 μM to 30 μM of Obefazimod, with monitoring of p24 antigen levels in culture supernatants across a span of 12 days. Obefazimod demonstrates a dose-responsive blockade of virus replication, with an IC50 value between 0.1 μM and 1 μM[1].

Obefazimod 动物研究

Animal study Humanized mice, which are reconstituted with human lymphoid cells, offer a fast, dependable, and consistent system for in vivo testing of Obefazimod's effectiveness. Initially, SCID mice are reconstituted with PBMCs and infected with the HIV-1 JR-CSF strain. These mice receive 20 mg/kg of Obefazimod orally twice daily for 15 days. Viral RNA measurements indicate that this oral Obefazimod regimen significantly lowers the viral load over the treatment period. Furthermore, FACS analysis of blood samples reveals that Obefazimod treatment hinders the loss of CD4+ cells post-infection in the reconstituted mice, thus normalizing the CD8+/CD4+ ratio to that seen in uninfected mice[1].

Obefazimod 参考文献

[1]Campos N, et al. Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology. 2015 Apr 9;12:30.

Obefazimod 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.76mL

2.95mL

1.48mL

29.52mL

5.90mL

2.95mL

Obefazimod 技术信息

CAS号1258453-75-6
分子式C16H10ClF3N2O
分子量 338.71
SMILES Code FC(F)(F)OC1=CC=C(NC2=NC3=C(Cl)C=CC=C3C=C2)C=C1
MDL No. MFCD31657325
别名 Abx464; SPL-464; BX-464
运输蓝冰
InChI Key OZOGDCZJYVSUBR-UHFFFAOYSA-N
Pubchem ID 49846599
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

DMSO: 105 mg/mL(310 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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