规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50μL*10mM(DMSO) | ¥99随货¥69 | 咨询 | |
100μL*10mM(DMSO) | ¥139随货¥99 | 咨询 | |
250μL*10mM(DMSO) | ¥259随货¥189 | 咨询 | |
500μL*10mM(DMSO) | ¥369随货¥259 | 咨询 | |
10mM*1mL(DMSO) | ¥516 | 咨询 | |
1mg | ¥329 | 咨询 | |
5mg | ¥469 | 咨询 | |
10mg | ¥778 | 咨询 | |
25mg | ¥1555 | 咨询 | |
50mg | ¥2489 | 咨询 | |
100mg | ¥3640 | 咨询 |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Obefazimod effectively suppresses HIV-1 production in cells infected with PBMC and macrophages. It exhibits robust inhibitory action against all tested HIV-1 subtypes, including B, C, and recombinant forms. Obefazimod also strongly prevents the replication of viral strains that possess mutations granting resistance to various therapeutic drugs in vitro. Unlike the antiviral medication 3TC, which shows limited activity against K65R and M184V mutant strains, Obefazimod successfully inhibits both. In an effort to extend the understanding of Obefazimod's impact on HIV-1 replication in other primary cells, treatments range from 0.01 μM to 30 μM of Obefazimod, with monitoring of p24 antigen levels in culture supernatants across a span of 12 days. Obefazimod demonstrates a dose-responsive blockade of virus replication, with an IC50 value between 0.1 μM and 1 μM[1]. |
Animal study | Humanized mice, which are reconstituted with human lymphoid cells, offer a fast, dependable, and consistent system for in vivo testing of Obefazimod's effectiveness. Initially, SCID mice are reconstituted with PBMCs and infected with the HIV-1 JR-CSF strain. These mice receive 20 mg/kg of Obefazimod orally twice daily for 15 days. Viral RNA measurements indicate that this oral Obefazimod regimen significantly lowers the viral load over the treatment period. Furthermore, FACS analysis of blood samples reveals that Obefazimod treatment hinders the loss of CD4+ cells post-infection in the reconstituted mice, thus normalizing the CD8+/CD4+ ratio to that seen in uninfected mice[1]. |
计算器 | ||||
存储液制备 | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 2.95mL 0.59mL 0.30mL | 14.76mL 2.95mL 1.48mL | 29.52mL 5.90mL 2.95mL |
CAS号 | 1258453-75-6 |
分子式 | C16H10ClF3N2O |
分子量 | 338.71 |
SMILES Code | FC(F)(F)OC1=CC=C(NC2=NC3=C(Cl)C=CC=C3C=C2)C=C1 |
MDL No. | MFCD31657325 |
别名 | Abx464; SPL-464; BX-464 |
运输 | 蓝冰 |
InChI Key | OZOGDCZJYVSUBR-UHFFFAOYSA-N |
Pubchem ID | 49846599 |
存储条件 | In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry,Store in freezer, under -20°C |
溶解方案 | DMSO: 105 mg/mL(310 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
|