There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Nitrosoglutathione (GSNO) acts as an exogenous donor of nitric oxide and a substrate for the rat alcohol dehydrogenase class III isoenzyme, which obstructs angiotensin II-dependent and -independent AT1 receptor responses within the cerebrovascular system.
体内研究
Administration of Nitrosoglutathione (GSNO, 8 mg/kg) induces a significant decline in systolic, diastolic, and mean arterial pressures in phenylephrine-induced hypertensive rats from day 14 to day 20.
Nitrosoglutathione at doses of 0.2 and 0.6 mg/kg significantly curtails superoxide production and mitigates NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, while concurrently augmenting endothelial NOS expression within the vascular structures of the flap.
体外研究
At a concentration of 250 μM, Nitrosoglutathione (GSNO) impedes 90% of the reaction to 0.1 μM serotonin (5-HT) and 40% of the reaction to 1.0 μM 5-HT in rings pre-treated with LY-83583, indicating an effect of GSNO that is independent of guanylate cyclase activity.
Nitrosoglutathione 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human blood B cells
50μM
1 hour pretreatment
GSNO treatment increased IL-10 expression and decreased IL-6 expression
Redox Biol. 2021 Sep;45:102053
Mouse splenic B cells
50μM
1 hour pretreatment
GSNO treatment increased IL-10 expression and decreased IL-6 expression
Redox Biol. 2021 Sep;45:102053
HEK293 cells
0.5 mM
4 hours
To verify the sites of SNO in PXR, results showed that the C307A mutation abolished GSNO-induced SNO-PXR.
JCI Insight. 2024 Jan 23;9(2):e172632
HepG2 cells
0.5 mM
4 hours
To examine whether PXR protein can be modified by SNO, results showed that PXR underwent SNO after GSNO treatment.
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