Nevirapine | 奈韦拉平 | BI-RG 587 | HIV-1 Reverse Transcriptase Inhibitor

首页 / / / / Nevirapine/奈伟拉平

Nevirapine/奈伟拉平 {[allProObj[0].p_purity_real_show]}

货号：A326622 同义名： 奈韦拉平 / BI-RG 587; HSDB 7164

Nevirapine是一种逆转录酶抑制剂，常与核苷类似物联合使用。

Nevirapine/奈伟拉平化学结构
CAS号：129618-40-2

Nevirapine/奈伟拉平 3D分子结构
CAS号：129618-40-2

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Nevirapine/奈伟拉平纯度/质量文件产品仅供科研

货号：A326622 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

Nevirapine/奈伟拉平生物活性

描述

Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM. Nevirapine itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki=270 μM)^[3]. At all doses (100, 200, 350, 500 μM) tested, nevirapine significantly inhibited cell proliferation after 48 h treatment. At high dose (500 μM), nevirapine significantly increased the percentage of apoptotic cells compared with control (P<0.01). At lower doses (200 μM and 350 μM), nevirapine did not induce cell apoptosis, but up-regulated NIS and THSR mRNA expression in a dose-dependent manner^[4]. Nevirapine also has an important role in preventing mother-to-child transmission of HIV. Nevirapine interacts with cytochrome P450 enzymes both as a substrate and as an inducer^[5]. Nevirapine (9 mg/kg, 18 mg/kg and 36 mg/kg) showed significant (P < 0.05) reduction in ulcer severity score and ulcer index as compared to the control in the models,.with corresponding increase in percentage inhibition^[6]. Nevirapine inhibits replication of multiple HIV-1 strains and clinical isolates in cultured human T cells, but has no activity against other retroviral RTs (including HIV-2 RT) or endogenous human DNA polymerases^[7].

Nevirapine/奈伟拉平动物实验

Species Oreochromis mossambicus Mice Mice	Animal Model Oreochromis mossambicus LDLr −/− and hA-I transgenic mice LINE-1a mice	Administration	Dosage	Frequency	Description	References
Oreochromis mossambicus	Oreochromis mossambicus	Water exposure	1.48 mg/L and 3.74 mg/L	30 days	The study investigated the effects of nevirapine and its mixture with antibiotics on the gonads of Oreochromis mossambicus. Female fish exposed to 3.74 mg/L nevirapine and its mixture showed significantly higher ovary indices, with increased vitellogenic oocyte atresia and vacuolation of the interstitial tissue observed in the ovaries.	Chemosphere. 2021 Jul;274:129900
Mice	LDLr −/− and hA-I transgenic mice	Oral	20 mg/kg	Once daily for 12 weeks	To study the effects of nevirapine on HDL cholesterol levels and reverse cholesterol transport, results showed that nevirapine significantly increased HDL cholesterol levels at week 4, but no significant difference was observed at weeks 8 and 12 compared to control	Atherosclerosis. 2009 Jun;204(2):418-23
Mice	LINE-1a mice	Oral	100 μg	Once daily for 4 weeks	Nevirapine treatment did not significantly affect the progression of ataxia in LINE-1a mice.	Neuron. 2022 Oct 19;110(20):3278-3287.e8

Nevirapine/奈伟拉平细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
293T cells		Function assay		Inhibition of wild type HIV1 reverse transcriptase in 293T cells, IC50=0.06 μM	16527484
CEM-SS cells		Function assay		Antiviral activity against HIV1 RF in CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay, EC50=1.5 nM	18222088
HeLa cells		Function assay		Antiviral activity against wild type HIV1 in HeLa cells by MAGI assay, IC50=0.053 μM	18665583
human C1866 cells		Cytotoxicity assay	72 h	Cytotoxicity against human C1866 cells after 72 hrs by MTT assay, EC50=0.04943 μM	21194939

Nevirapine/奈伟拉平参考文献

[1]Mangiacasale R, Pittoggi C, et al. Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene. 2003 May 8;22(18):2750-61.

[2]Erickson DA, Mather G, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95.

[3]Erickson DA, Mather G, Trager WF, Levy RH, Keirns JJ. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95

[4]Dong JJ, Zhou Y, Liu YT, Zhang ZW, Zhou XJ, Wang HJ, Liao L. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370(1-2):113-8

[5]Milinkovic A, Martínez E. Nevirapine in the treatment of HIV. Expert Rev Anti Infect Ther. 2004 Jun;2(3):367-73

[6]Onasanwo SA, Adeyemi JA, Latinwo GG, Faborode SO, Mishra V. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44(3):251-9

[7]Bardsley-Elliot A, Perry CM. Nevirapine: a review of its use in the prevention and treatment of paediatric HIV infection. Paediatr Drugs. 2000 Sep-Oct;2(5):373-407

Nevirapine/奈伟拉平实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.55mL

7.51mL

3.76mL

Nevirapine/奈伟拉平技术信息

CAS号	129618-40-2
分子式	C₁₅H₁₄N₄O
分子量	266.3
SMILES Code	O=C1C2=CC=CN=C2N(C3CC3)C4=NC=CC(C)=C4N1
MDL No.	MFCD00866928

别名	奈韦拉平 ;BI-RG 587; HSDB 7164; BIRG 0587; NSC 641530
运输	蓝冰
InChI Key	NQDJXKOVJZTUJA-UHFFFAOYSA-N
Pubchem ID	4463

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature

溶解方案

细胞实验：

DMSO: 15 mg/mL(56.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

Nevirapine/奈伟拉平 {[allProObj[0].p_purity_real_show]}

Nevirapine/奈伟拉平纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Nevirapine/奈伟拉平质控信息

Nevirapine/奈伟拉平生物活性

Nevirapine/奈伟拉平动物实验

Nevirapine/奈伟拉平细胞研究

Nevirapine/奈伟拉平参考文献

Nevirapine/奈伟拉平实验方案

Nevirapine/奈伟拉平技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Nevirapine/奈伟拉平 {[allProObj[0].p_purity_real_show]}

Nevirapine/奈伟拉平 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Nevirapine/奈伟拉平 质控信息

Nevirapine/奈伟拉平 生物活性

Nevirapine/奈伟拉平 动物实验

Nevirapine/奈伟拉平 细胞研究

Nevirapine/奈伟拉平 参考文献

Nevirapine/奈伟拉平 实验方案

Nevirapine/奈伟拉平 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Nevirapine/奈伟拉平纯度/质量文件产品仅供科研

Nevirapine/奈伟拉平质控信息

Nevirapine/奈伟拉平生物活性

Nevirapine/奈伟拉平动物实验

Nevirapine/奈伟拉平细胞研究

Nevirapine/奈伟拉平参考文献

Nevirapine/奈伟拉平实验方案

Nevirapine/奈伟拉平技术信息