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Natamycin/纳他霉素 {[allProObj[0].p_purity_real_show]}

货号：A204100 同义名： Pimaricin; Antibiotic A 5283

Natamycin是一种天然存在的多烯大环内酯类抗生素和抗真菌药物，用于治疗眼部和食品行业中奶酪和香肠表面处理的真菌感染。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Natamycin/纳他霉素 化学结构 CAS号：7681-93-8
Natamycin/纳他霉素 化学结构
CAS号：7681-93-8
Natamycin/纳他霉素 3D分子结构
CAS号：7681-93-8
Natamycin/纳他霉素 化学结构 CAS号：7681-93-8
Natamycin/纳他霉素 3D分子结构 CAS号：7681-93-8
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Natamycin/纳他霉素 纯度/质量文件 产品仅供科研

货号：A204100 标准纯度： {[allProObj[0].p_purity_real_show]}
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Natamycin/纳他霉素 生物活性

描述 Natamycin is an important polyene macrolide antifungal agent produced by several Streptomyces strains and is widely used as a food preservative and fungicide in food, medicinal and veterinary products[3]. Natamycin treatment was associated with significantly better clinical and microbiological outcomes than voriconazole treatment for smear-positive filamentous fungal keratitis, with much of the difference attributable to improved results in Fusarium cases[4]. The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro. The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and to azithromycin 50 μg/ml against Fusarium solani species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC90 from 64 to 0.031 μg/ml. No antagonism was observed[5]. NAT-SLNs (Natamycin solid lipid nanoparticles) were found to be non-irritating to corneal tissue. NAT-SLNs had a prolonged drug release rate, that improved corneal penetration, and increased antifungal activity without cytotoxic effects on corneal tissues. NAT-SLNs represent a promising ocular delivery system for treatment of deep corneal keratitis[6].

Natamycin/纳他霉素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00997035 Corneal Ulcer ... 展开 >> Eye Infections, Fungal 收起 << Phase 3 Completed - United States, California ... 展开 >> Proctor Foundation, UCSF San Francisco, California, United States, 94143 India Aravind Eye Hospital Coimbatore, Tamil Nadu, India Aravind Eye Hospitals Madurai, Tamil Nadu, India Aravind Eye Hospital Pondicherry, Tamil Nadu, India Aravind Eye Hospital Tirunelveli, Tamil Nadu, India Nepal Bharatpur Eye Hospital Bharatpur, Chitwan, Nepal Lumbini Eye Institute Bhairahawa, Lumbini, Nepal 收起 <<
NCT02865876 Keratitis Phase 3 Unknown March 2017 Mexico ... 展开 >> Instituto de Oftalmologia Conde de Valenciana Recruiting Mexico City, Mexico, 06800 Contact: Lucero Pedro-aguilar, MD       lu.pedroaguilar@gmail.com    Contact: Enrique Graue-Hernandez, MD, MSc       egraueh@gmail.com 收起 <<
NCT00516399 Fungal Keratitis Phase 3 Terminated(The DSMC decided it... 展开 >> appeared futile to attempt to demonstrate non-inferiority of povidone-iodine to Natamycin.) 收起 << - -

Natamycin/纳他霉素 参考文献

[1]te Welscher YM, Jones L,et al. Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Antimicrob Agents Chemother. 2010 Jun;54(6):2618-25. doi: 10.1128/AAC.01794-09. Epub 2010 Apr 12.

[2]te Welscher YM, ten Napel HH, et al. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. J Biol Chem. 2008 Mar 7;283(10):6393-401.

[3]Wu H, Liu W, Dong D, Li J, Zhang D, Lu C. SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02. J Ind Microbiol Biotechnol. 2014;41(1):163‐172

[4]Prajna NV, Krishnan T, Mascarenhas J, et al. The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. 2013;131(4):422‐429

[5]Guo H, Zhou L, He Y, Gao C, Han L, Xu Y. Natamycin and Azithromycin Are Synergistic In Vitro against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates. Antimicrob Agents Chemother. 2018;62(7):e00077-18. Published 2018 Jun 26

[6]Khames A, Khaleel MA, El-Badawy MF, El-Nezhawy AOH. Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization. Int J Nanomedicine. 2019;14:2515‐2531

Natamycin/纳他霉素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.50mL

0.30mL

0.15mL

7.51mL

1.50mL

0.75mL

15.02mL

3.00mL

1.50mL

Natamycin/纳他霉素 技术信息

CAS号7681-93-8
分子式C33H47NO13
分子量 665.73
SMILES Code OC([C@H]1[C@@](C[C@H](/C=C/C=C/C=C/C=C/C[C@@H](C)OC2=O)O[C@@](O[C@H](C)[C@@H](O)[C@@H]3N)([H])[C@H]3O)([H])O[C@](O)(C[C@H](C[C@]4([H])[C@@H](/C=C/2)O4)O)C[C@@H]1O)=O
MDL No. MFCD00135085
别名 Pimaricin; Antibiotic A 5283; Delvolan; Tennecetin; Synogil; Myprozine; Mycophyt; E 235; Delvocid; CL 12,625
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 16 mg/mL(24.03 mM)，配合低频超声，并调节pH至6，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Tags: Natamycin | Pimaricin;Antibiotic A 5283;Delvolan;Tennecetin;Synogil;Myprozine;Mycophyt;E 235;Delvocid;CL 12,625 | Antifungal | AmBeed-信号通路专用抑制剂 | Natamycin/纳他霉素 纯度/质量文件 | Natamycin/纳他霉素 生物活性 | Natamycin/纳他霉素 临床数据 | Natamycin/纳他霉素 参考文献 | Natamycin/纳他霉素 实验方案 | Natamycin/纳他霉素 技术信息

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