There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Nanchangmycin is a polyether antibiotic derived from Streptomyces nanchangensis NS3226, known for its inhibitory action against gram-positive bacteria[1]. Nanchangmycin, recognized as a broad-spectrum antiviral, is effective against the Zika virus. Nanchangmycin is a strong inhibitor of Zika virus (ZIKV) entry in all tested cell types, including primary cells that are physiologically significant. It effectively reduces infections by all three ZIKV strains in these cell types, with IC50 values ranging from 0.1 to 0.4 μM, and exhibits low toxicity within these concentrations. Additionally, Nanchangmycin also inhibits the Dengue virus (DENV) across various cell types[2].
Nanchangmycin/南昌霉素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
LP1
1-4 µM
24 h
To evaluate the effect of Nanchangmycin on c-Maf transcriptional activity, results showed Nanchangmycin downregulated the expression of c-Maf target genes CCND2 and ITGB7.
Cell Death Dis. 2020 Sep 30;11(9):818.
MM1.S
1-4 µM
24 h
To evaluate the effect of Nanchangmycin on c-Maf transcriptional activity, results showed Nanchangmycin downregulated the expression of c-Maf target genes CCND2 and ITGB7.
Cell Death Dis. 2020 Sep 30;11(9):818.
RPMI-8226
1-4 µM
24 h
To evaluate the effect of Nanchangmycin on c-Maf transcriptional activity, results showed Nanchangmycin downregulated the expression of c-Maf target genes CCND2 and ITGB7.
Cell Death Dis. 2020 Sep 30;11(9):818.
HEK293T
5 µM
24 h
To screen compounds inhibiting the Otub1/c-Maf axis, Nanchangmycin was found to significantly suppress luciferase activity.
Cell Death Dis. 2020 Sep 30;11(9):818.
MDA-MB-231
5 μM
72 h
Evaluate the inhibitory effect of Nanchangmycin on breast cancer stem cells (BCSCs), results showed Nanchangmycin significantly reduced the proportion of BCSCs
ACS Pharmacol Transl Sci. 2018 Oct 12;1(2):84-95.
Human trophoblast cell line Jeg-3
2.8 μM
36 hours
Screening for compounds that inhibit ZIKV infection, nanchangmycin showed potent inhibition in Jeg-3 cells
Cell Rep. 2017 Jan 17;18(3):804-815.
Human microvascular endothelial cells (HBMEC)
0.7 μM
24 hours
Screening for compounds that inhibit ZIKV infection, nanchangmycin showed potent inhibition in HBMEC cells
Cell Rep. 2017 Jan 17;18(3):804-815.
Human osteosarcoma cells (U2OS)
0.7 μM
48 hours
Screening for compounds that inhibit ZIKV infection, nanchangmycin showed potent inhibition across all tested cell types
To evaluate the anti-myeloma activity of Nanchangmycin in vivo, results showed Nanchangmycin significantly suppressed tumor growth without obvious toxicity.
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