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/ NADPH tetrasodium salt

NADPH tetrasodium salt {[allProObj[0].p_purity_real_show]}

货号：A341469 同义名： 还原型辅酶II / NADPH (sodium salt); Nicotinamide adenine dinucleotide phosphate

NADPH tetrasodium salt是一种普遍存在的辅因子和生物还原剂，作为许多生物反应中的电子供体。

NADPH tetrasodium salt 化学结构 CAS号：2646-71-1
NADPH tetrasodium salt 化学结构
CAS号：2646-71-1
NADPH tetrasodium salt 3D分子结构
CAS号：2646-71-1
NADPH tetrasodium salt 化学结构 CAS号：2646-71-1
NADPH tetrasodium salt 3D分子结构 CAS号：2646-71-1
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NADPH tetrasodium salt 纯度/质量文件 产品仅供科研

货号：A341469 标准纯度： {[allProObj[0].p_purity_real_show]}
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NADPH tetrasodium salt 生物活性

描述 NADPH tetrasodium salt is a cofactor, used to donate electrons and hydrogens to reactions catalyzed by some enzymes. NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions. NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety[1]. NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species[2]. It is also used for the synthesis of lipids and cholesterol and during the process of fatty acid chain elongation[3].

NADPH tetrasodium salt 细胞实验

Cell Line
Concentration Treated Time Description References
HT22 cells 10 μM 4 hours NADPH preincubation significantly reduced RSL3-induced lipid peroxidation, indicating NADPH's anti-ferroptosis effect mediated by NMT2. Redox Biol. 2024 Jul;73:103176
Primary cortical neurons from ICR mouse embryos 10 μM 4 hours NADPH preincubation significantly inhibited KA-induced lipid peroxidation, protecting neurons from excitotoxic injury. Redox Biol. 2024 Jul;73:103176
Neonatal rat cardiomyocytes (NRCMs) 60, 500 nM 10 hours of oxygen-glucose deprivation (OGD) followed by restoration NADPH significantly rescued cell viability and inhibited OGD/R-induced apoptosis, increased AMPK phosphorylation, and downregulated mTOR phosphorylation. Acta Pharmacol Sin. 2020 Apr;41(4):535-545

NADPH tetrasodium salt 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
ICR mice KA-induced excitotoxicity model Intravenous injection 2.5 mg/kg Every 24 hours for 48 hours Exogenous NADPH supplementation significantly alleviated KA-induced ferroptosis, maintaining mitochondrial morphology and reducing lipid peroxidation. Redox Biol. 2024 Jul;73:103176
Rats Myocardial ischemia/reperfusion (I/R) injury model Intravenous injection 4, 8, 16 mg/kg/d Single administration at the onset of reperfusion NADPH significantly decreased myocardial infarct size, reduced serum levels of lactate dehydrogenase (LDH) and cardiac troponin I (cTn-I), decreased the apoptotic rate of cardiomyocytes, and protected mitochondrial function. Acta Pharmacol Sin. 2020 Apr;41(4):535-545

NADPH tetrasodium salt 参考文献

[1]Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 2008 Jul;275(13):3249-77

[2]Sutherland, M.W., Nelson, J., Harrison, G., et al. Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar machrophages. Arch. Biochem. Biophys. 1985;243(2), 325-331.

[3]Tserng, K.Y., and Jin, S.J. NADPH-dependent reductive metabolism of cis-5 unsaturated fatty acids. A revised pathway for the β-oxidation of oleic acid. The Journal of Biological Chemisty. 1990; 266(18), 11614-11620.

NADPH tetrasodium salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.20mL

0.24mL

0.12mL

6.00mL

1.20mL

0.60mL

12.00mL

2.40mL

1.20mL

NADPH tetrasodium salt 技术信息

CAS号2646-71-1
分子式C21H26N7Na4O17P3
分子量 833.35
SMILES Code O=P(O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)N3C=CCC(C(N)=O)=C3)(O[Na])=O)(O[Na])=O)N4C5=C(N=C4)C(N)=NC=N5)(O[Na])O[Na]
MDL No. MFCD00036263
别名 还原型辅酶II ;NADPH (sodium salt); Nicotinamide adenine dinucleotide phosphate
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

H2O: 35 mg/mL(42 mM)

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: NADPH tetrasodium salt | NADPH (sodium salt);Nicotinamide adenine dinucleotide phosphate | 还原型辅酶II | Additive and Auxiliary Reagent | Vitamin | AmBeed-信号通路专用抑制剂 | NADPH tetrasodium salt 纯度/质量文件 | NADPH tetrasodium salt 生物活性 | NADPH tetrasodium salt 参考文献 | NADPH tetrasodium salt 实验方案 | NADPH tetrasodium salt 技术信息

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