Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His)
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货号：A2900844同义名：
重组小鼠RANK L蛋白(HEK293, N-6His)
/ Recombinant Mouse RANK L (N-6His); Tumor necrosis factor ligand superfamily member 11
Recombinant Mouse RANK L (N-6His)是小鼠来源的重组蛋白，在人源细胞中表达，带有N端6×His标签。该蛋白为小鼠肿瘤坏死因子配体超家族成员11（Tnfsf11），广泛表达于包括T细胞及富含T细胞的器官（如胸腺和淋巴结）在内的多种细胞中，可与TNFRSF11B/OPG和TNFRSF11A/RANK结合，参与调节T细胞与树突状细胞间的相互作用、T细胞依赖性免疫应答，并在恶性肿瘤体液性高钙血症中增强骨吸收，促进树突状细胞刺激初始T细胞增殖的能力。
Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His) 化学结构 CAS号：N/A
Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His) 3D分子结构 CAS号：N/A
Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His) 质控信息
Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His) 生物活性
描述
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl,8% Trehalose，2% Mannitol,0.05% Tween80，pH 9.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Mouse RANK L (N-6His)/小鼠RANK L蛋白(HEK293, N-6His) 技术信息
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