货号:A2926542
同义名:
重组小鼠OX40L蛋白(N-Fc, HEK293)
/ Recombinant Mouse OX40L (N-Fc, HEK293); Tumor necrosis factor ligand superfamily member 4
Recombinant Mouse OX40L (N-Fc, HEK293)是小鼠来源的重组蛋白,在HEK293人源细胞中表达,带有N端Fc标签。该蛋白即OX40配体(又称CD252),属于TNF/TNF受体超家族的单次跨膜II型蛋白,主要由树突细胞、巨噬细胞和B细胞表达,通过与T细胞表面的OX40受体相互作用,促进T细胞活化与存活,并有助于效应T细胞向记忆T细胞转化,激活TRAF2/3/5信号通路,延长CD4+ Th细胞存活并增强记忆T细胞生成。


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| 描述 | OX40 ligand (OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptor superfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. OX40L–OX40 co-stimulation leads to activation of TNF receptor associated factor (TRAF) 2, 3 and 5. This pathway has been shown to prolong the survival of effector CD4+Th cells as well as contributes to generation of memory T cells. |
| 蛋白种属 | Mouse |
| 表达系统 | Human Cells |
| 标签 | N-Fc |
| 蛋白表达区间 | Ser51-Leu198 |
| 蛋白编号 | P43488 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 43.1 KDa |
| SMILES Code | NONE |
| 别名 | 重组小鼠OX40L蛋白(N-Fc, HEK293) ;Recombinant Mouse OX40L (N-Fc, HEK293); Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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