货号:A2900790
同义名:
重组小鼠IL-2蛋白(E.coli, tag free)
/ Recombinant Mouse IL-2; aldesleukin
Recombinant Mouse IL-2是小鼠来源的重组蛋白,在大肠杆菌中表达,为无标签蛋白。该蛋白即白细胞介素2,又称T细胞生长因子,属于细胞因子家族成员,成熟蛋白与人和大鼠IL-2分别有56%和73%氨基酸序列同源性,由多种免疫细胞产生,通过刺激T细胞在免疫系统功能、耐受和免疫方面发挥关键作用,可自然抑制自身免疫。


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| 描述 | Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL2 shares 56% and 73% aa sequence identity with human and rat IL2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity. |
| 蛋白种属 | Mouse |
| 表达系统 | E.coli |
| 标签 | Tag free |
| 蛋白表达区间 | Ala21-Gln169 |
| 蛋白编号 | P04351 |
| 内毒素 | < 0.01 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM Sodium Citrate, 0.2% Tween 80, pH 3.0. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 17.4 KDa |
| SMILES Code | NONE |
| 别名 | 重组小鼠IL-2蛋白(E.coli, tag free) ;Recombinant Mouse IL-2; aldesleukin; interleukin 2; interleukin-2; IL-2; IL2; T-cell growth facter; T cell growth factor; TCGF |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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