货号:A2925228
同义名:
重组小鼠CD16蛋白(C-6His, HEK293)(Ala31-Thr215)
/ Recombinant Mouse CD16 (C-6His, HEK293)(Ala31-Thr215); Low affinity immunoglobulin gamma Fc region receptor III
Recombinant Mouse CD16 (C-6His, HEK293)是来自小鼠的重组蛋白,在HEK293人源细胞中表达,带有C端6×His标签。该蛋白为低亲和力IgG Fc区受体III(CD16),属于Ig超家族成员,具有两个胞外Ig样结构域,表达于多种髓系与淋巴细胞,与Fc R gamma结合后可在配体结合时传递激活信号,参与抗体依赖性细胞毒作用、吞噬及免疫应答调控。


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| 描述 | Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity. |
| 蛋白种属 | Mouse |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Ala31-Thr215 |
| 蛋白编号 | P08508 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 10% Sucrose, 8% Mannitol, 0.05% Tween 80, pH 7.0. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 22 KDa |
| SMILES Code | NONE |
| 别名 | 重组小鼠CD16蛋白(C-6His, HEK293)(Ala31-Thr215) ;Recombinant Mouse CD16 (C-6His, HEK293)(Ala31-Thr215); Low affinity immunoglobulin gamma Fc region receptor III; Fcgr3; Fc gamma Receptor III; CD-antigen 16; CD16; FcRIII; IgG Fc receptor III |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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