C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free) 技术信息
CAS号
N/A
分子量
8.5 KDa
SMILES Code
NONE
别名
重组小鼠CCL2蛋白(E.coli, tag free)
;Recombinant Mouse CCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Platelet-derived growth factor-inducible protein JE; Small-inducible cytokine A2; Ccl2; Je; Mcp1; Scya2
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free)
|Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free)
| 重组小鼠CCL2蛋白(E.coli, tag free)
| Recombinant Mouse CCL2
| C-C motif chemokine 2
| Monocyte chemoattractant protein 1
| Monocyte chemotactic protein 1
| MCP-1
| Platelet-derived growth factor-inducible protein JE
| Small-inducible cytokine A2
| Ccl2
| Je
| Mcp1
| Scya2
| N/A
| Chemokine & Receptors
| Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free) 纯度/质量文件
| Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free) 生物活性
| Mouse CCL2/小鼠CCL2蛋白(E.coli, tag free) 技术信息
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