货号:A2924701
同义名:
重组小鼠APRIL蛋白(N-Fc, HEK293)
/ Recombinant Mouse APRIL (N-Fc, HEK293); A proliferation-inducing ligand
Recombinant Mouse APRIL (N-Fc, HEK293) 是来自小鼠的重组蛋白,在HEK293人源细胞中表达,带有N端Fc标签。该蛋白为肿瘤坏死因子配体超家族成员13(TNFSF13),也称为APRIL,是一种由32 kDa前体蛋白经加工后产生的17 kDa可溶性细胞因子,能够与TACI和BCMA受体结合,调节肿瘤细胞生长,主要在转化细胞系、结肠癌、甲状腺癌、淋巴组织及单核巨噬细胞中高表达,具有免疫调节功能。


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| 描述 | Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. TNFSF13 is a Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA and plays a role in the regulation of tumor cell growth. It expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. Its expression by CD4+ T cells inhibits the production of Th2 cytokines and allergic inflammation. |
| 蛋白种属 | Mouse |
| 表达系统 | Human Cells |
| 标签 | N-Fc |
| 蛋白表达区间 | Ala96-Leu240 |
| 蛋白编号 | AAG22534.1 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Sucrose, 0.05% Tween 80, pH 6.0. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 42.7 KDa |
| SMILES Code | NONE |
| 别名 | 重组小鼠APRIL蛋白(N-Fc, HEK293) ;Recombinant Mouse APRIL (N-Fc, HEK293); A proliferation-inducing ligand; TNFSF13; TALL-2; TRDL-1; CD256 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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