货号:A2900872
同义名:
重组小鼠4-1BB蛋白(HEK293, C-Fc)
/ Recombinant Mouse 4-1BB (C-Fc); Secreted CD137 antigen
Recombinant Mouse 4-1BB (C-Fc)是小鼠来源的重组蛋白,在人源细胞中表达,带有C端Fc标签。该蛋白为肿瘤坏死因子受体超家族成员9(TNFRSF9),可被淋巴细胞激活诱导表达,主要在活化的T细胞(尤其是CD8+ T细胞)、树突状细胞、滤泡树突状细胞、NK细胞及炎症部位血管壁细胞中表达。作为TNFSF9/4-1BBL的受体,它能激活T细胞,增强增殖、IL-2分泌、存活及细胞毒活性,有助于提升抗肿瘤免疫应答。


| 规格 | 价格 | 会员价 | 库存 | 数量 | |||
|---|---|---|---|---|---|---|---|
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| 描述 | Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. |
| 蛋白种属 | Mouse |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Val24-Leu187 |
| 蛋白编号 | P20334 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 44.7 KDa |
| SMILES Code | NONE |
| 别名 | 重组小鼠4-1BB蛋白(HEK293, C-Fc) ;Recombinant Mouse 4-1BB (C-Fc); Secreted CD137 antigen ; Tumor necrosis factor receptor superfamily member 9 ; Tnfrsf9 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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