There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To investigate the effect of inhibiting glutamine and serine metabolism on pulmonary hypertension. Results showed that inhibition of GLS1 and SHMT1 reduced pulmonary vascular collagen content and vascular stiffness, improving symptoms of pulmonary hypertension.
Cell Metab. 2024 Jun 4;36(6):1335-1350. e8
Male Sprague-Dawley rats
MCT-induced pulmonary arterial hypertension model
Subcutaneous injection
60 mg/kg
Single injection, duration of 4 weeks
To evaluate the mechanisms of right ventricular failure in the MCT-induced pulmonary arterial hypertension model. Results showed increased macrophage infiltration and NLRP3 inflammasome activation in the right ventricle of MCT rats, leading to decreased right ventricular function and fibrosis.
Am J Respir Crit Care Med. 2022 Sep 1;206(5):608-624
Rats
Monocrotaline-induced pulmonary hypertension model
Intraperitoneal injection
60 mg/kg
Single injection, observed for 28 days
To investigate the relevance of A2B1 inhibition in mitigating pulmonary hypertension severity
Circulation. 2022 Oct 18;146(16):1243-1258
Sprague-Dawley rats
Pulmonary arterial hypertension (PAH) model
Subcutaneous injection
60 mg/kg
Single injection, duration of 4 weeks
Investigated the mechanism of RV fibrosis in MCT-induced PAH rats, showing that DCA treatment reduced RV fibrosis and improved RV function.
Circ Res. 2020 Jun 5;126(12):1723-1745
Mice
Monocrotaline-induced pulmonary hypertension model
Subcutaneous injection
600 mg/kg
Weekly for 4 weeks
Induce pulmonary hypertension and assess right ventricular hypertrophy and pulmonary vascular remodeling
Cardiovasc Res. 2016 Jun 1;110(3):319-30
Sprague-Dawley rats
Monocrotaline-induced pulmonary hypertension model
Subcutaneous injection
60 mg/kg body weight
Single injection, lasting 21 days
To evaluate the therapeutic effect of SecinH3 on monocrotaline-induced pulmonary hypertension. Results showed that SecinH3 significantly improved right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH), and arterial muscularization, and restored BMPRII expression.
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