货号:A259020
同义名:
二甲胺四环素盐酸盐
/ CL 59806; Minocycline hydrochloride
Minocycline HCl是一种口服有效、能透过血脑屏障的半合成四环素类抗生素,亦为缺氧诱导因子 (HIF-1α) 抑制剂。同时,Minocycline hydrochloride 具有抗癌、抗炎和谷氨酸拮抗作用。
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描述 | Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic. Minocycline hydrochloride on the GO-modified (graphene oxide) titanium surface (M@GO-Ti) showed a slow release behavior and exhibited excellent antibacterial activity with the synergistic effect of contact-killing and release-killing by GO and minocycline hydrochloride, respectively[3]. Minocycline hydrochloride is an effective sclerotizing agent. Percutaneous sclerosis with Minocycline hydrochloride is a very effective and promising nonsurgical treatment for patients with symptomatic simple cysts, and it can be performed without major complications[4]. MH-loaded (Minocycline Hydrochloride) in situ cubic liquid crystal possessed of sustained release ability and periodontal clinical symptoms improvement[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02946788 | Acne Vulgaris | Phase 2 | Completed | - | United States, Florida ... 展开 >> Study Center Coral Gables, Florida, United States, 33146 United States, Nevada Study Center Las Vegas, Nevada, United States, 89128 收起 << |
NCT01173692 | Oropharynx Cancer | Phase 2 | Active, not recruiting | July 2019 | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
NCT02355977 | Chronic Periodontitis | Phase 4 | Completed | - | - |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.12mL 2.02mL 1.01mL |
20.25mL 4.05mL 2.02mL |
CAS号 | 13614-98-7 |
分子式 | C23H28ClN3O7 |
分子量 | 493.94 |
SMILES Code | O=C(C1=C(O)[C@@H](N(C)C)[C@@](C[C@@]2([H])C(C(C3=C(O)C=CC(N(C)C)=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N.[H]Cl |
MDL No. | MFCD00083669 |
别名 | 二甲胺四环素盐酸盐 ;CL 59806; Minocycline hydrochloride |
运输 | 蓝冰 |
InChI Key | WTJXVDPDEQKTCV-VQAITOIOSA-N |
Pubchem ID | 54685925 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere, room temperature |
溶解方案 |
DMSO: 18 mg/mL(36.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 9 mg/mL(18.22 mM),配合低频超声助溶 |