There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Meropenem Trihydrate is a novel carbapenem antibiotic for injection[3]. Meropenem, like imipenem and various experimental penems, may overcome the resistance problems presented by Class I beta-lactamases[4]. Antibacterial drugs significantly inhibit hPON1 activity with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro[5]. Meropenem can cause severe liver injury and that early recognition of drug-induced liver injury is important[6]. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Radiostelization is a promising, alternative method for obtaining sterile meropenem[7].
Meropenem Trihydrate/美罗培南三水合物 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Red blood cells
1000 mg/mL
Evaluate hemolytic activity, results showed no hemolysis even at 1000 mg/mL concentration.
Acta Pharm Sin B. 2021 Jan;11(1):203-221
NDM-1-negative E. coli
0.03 µg mL−1
24 hours
Evaluate the antibacterial activity of Meropenem against NDM-1-negative E. coli, showing an MIC of 0.03 µg mL−1
Nat Commun. 2018 Jan 30;9(1):439
NDM-1-positive E. coli
16 µg mL−1
24 hours
Evaluate the antibacterial activity of Meropenem against NDM-1-positive E. coli, showing an MIC of 16 µg mL−1
Nat Commun. 2018 Jan 30;9(1):439
Meropenem Trihydrate/美罗培南三水合物 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c mice
Sepsis mouse model
Subcutaneous injection
10 mg/kg (MEM), 30 mg/kg (19bh)
Single dose, monitored for 96 hours
Evaluate the in vivo efficacy of compound 19bh combined with MEM, results showed that the combination treatment was markedly effective in treating infections caused by NDM-1 positive strain and prolonged the survival time of sepsis mice.
Acta Pharm Sin B. 2021 Jan;11(1):203-221
BALB/c mice
Peritonitis model
Intraperitoneal injection
5 mg/kg
Twice daily until the endpoint of the experiment
Evaluate the efficacy of Meropenem and CBS combination therapy in mice infected with NDM-1-positive bacteria, showing a significant increase in survival rate
Nat Commun. 2018 Jan 30;9(1):439
Mice
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) model
Oral (drinking water)
0.625 g/L (drinking water)
Daily, from day 3 to day 15 post-transplantation
To study the effect of meropenem on GVHD, finding that meropenem treatment aggravates colonic GVHD, leading to thinning of the colonic mucus layer and bacterial translocation
Cell. 2022 Sep 29;185(20):3705-3719. e14
Mice
Escherichia coli sepsis model
Intravenous injection
10 mg/kg
Single dose at 2 or 8 hours post-infection
To evaluate the effect of Meropenem on the sepsis model, results showed that Meropenem significantly reduced bacterial load in heart, lung, and kidney, but had less effect on spleen and liver.
Nat Commun. 2023 Jun 17;14(1):3603
C57BL/6 mice
Pneumonia and bacteremia models
Meropenem subcutaneously, mAbs intravenously
Meropenem: 7.5 mg/kg (O1 strain) or 50 mg/kg (O2 strain); mAbs: 1 mg/kg (KPE33) or 0.2 mg/kg (KPN42)
Evaluate synergistic therapeutic effect of anti-O antigen mAbs with meropenem, showing combination therapy significantly improved survival against resistant strains.
Nat Commun. 2017 Dec 8;8(1):1991
Mice
Tissue cage implant infection model
Intraperitoneal injection
100 mg/kg
Once daily for 10 days
Evaluate the efficacy of Meropenem combined with phage Paride in chronic infections. Results showed that the combination significantly reduced bacterial loads.
Nat Commun. 2024 Jan 2;15(1):175
Swiss Webster mice
Gestational sepsis model
Subcutaneous injection
10 mg/kg
After 5 h, 24 h, 48 h, and 72 h
To evaluate the therapeutic effect of meropenem on gestational sepsis and its impact on offspring. Results showed that meropenem treatment alleviated sepsis symptoms, but offspring still exhibited abnormalities in neurodevelopment and behavior.
J Neuroinflammation. 2021 Feb 25;18(1):60
Mice
Antibiotic-induced gut dysbiosis model
Oral gavage
21.6 mg
Twice daily (days 0-6), once daily (days 7-11), for 11 days
To investigate the effects of antibiotic-induced gut dysbiosis on cognitive function. Results showed that meropenem, in combination with other antibiotics, significantly altered gut microbiota composition, reduced bacterial metabolite levels in the colon and plasma, and impaired novel object recognition memory in mice.
Brain Behav Immun. 2016 Aug;56:140-55
Mice
Pseudomonas aeruginosa keratitis model
Topical administration
0.5 mg/mL
Every 8 hours for 72 hours
To evaluate the efficacy of meropenem in combination with LasB inhibitor (R)-30 for treating Pseudomonas aeruginosa keratitis. Results showed that the combination significantly reduced bacterial load and clinical symptoms, outperforming meropenem alone.
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