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Menthone/薄荷酮 {[allProObj[0].p_purity_real_show]}

货号:A775007 同义名: 孟酮 / p-Menthan-3-one; NSC 9280

Menthone, a natural product isolated and purified from the herbs of Mentha canadensis L., enhances the skin permeability by disordering the ordered organization of SC lipids and extracts part of SC lipids, while pulegone appears to promote drug transport across the skin only by extracting part of SC lipids.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Menthone/薄荷酮 化学结构 CAS号:10458-14-7
Menthone/薄荷酮 化学结构
CAS号:10458-14-7
Menthone/薄荷酮 3D分子结构
CAS号:10458-14-7
Menthone/薄荷酮 化学结构 CAS号:10458-14-7
Menthone/薄荷酮 3D分子结构 CAS号:10458-14-7
规格 价格 会员价 库存 数量
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Menthone/薄荷酮 纯度/质量文件 产品仅供科研

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Menthone/薄荷酮 生物活性

描述 Menthone, a natural product isolated and purified from the herbs of Mentha canadensis L., enhances the skin permeability by disordering the ordered organization of SC (stratum corneum) lipids and extracts part of SC lipids, while pulegone appears to promote drug transport across the skin only by extracting part of SC lipids[3]. Vit C and menthone at higher dose have a good compensatory effect with significant reduction in DNA damages in sperm cells by reversing the adverse effect of ACV (Acyclovir) on the reproductive system in male rat[4]. Menthone, a component of peppermint oil, was given p.o. to groups of 10 male and 10 female rats at dose levels of 0, 200, 400 and 800 mg/kg b.w./day, respectively, for 28 days. After 19 days the dose was reduced to 400 mg/kg b.w. in the female group receiving the highest dose. Analyses of plasma showed a dose-dependent decrease in creatinine content and a dose-dependent increase in alkaline phosphatase activity and bilirubin. The relative weights of liver and spleen were increased. Cyst-like spaces were seen histopathologically in the white matter of the cerebellum of the two highest dose groups[5].

Menthone/薄荷酮 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02106403 Skin Care Not Applicable Completed - China, Guangdong ... 展开 >> Guangzhou Landproof Testing Technology Co., LTD Guangzhou, Guangdong, China, 510635 收起 <<
NCT03475836 Cognitive Change ... 展开 >> Affect 收起 << Not Applicable Completed - -
NCT02106403 - Completed - -

Menthone/薄荷酮 参考文献

[1]Lan Y, Wang J, et al. Effect of menthone and related compounds on skin permeation of drugs with different lipophilicity and molecular organization of stratum corneum lipids. Pharm Dev Technol. 2016;21(4):389-98.

[2]Hu G, Yuan X, et al. Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule. Int Immunopharmacol. 2015 Feb;24(2):191-7.

[3]Lan Y, Wang J, Li H, Zhang Y, Chen Y, Zhao B, Wu Q. Effect of menthone and related compounds on skin permeation of drugs with different lipophilicity and molecular organization of stratum corneum lipids. Pharm Dev Technol. 2016;21(4):389-98

[4]Toghiani S, Hayati Roudbari N, Dashti GR, Rouzbehani S. The effects of vitamin C and menthone on acyclovir induced DNA damage in rat spermatozoa: An experimental study. Int J Reprod Biomed. 2018 Nov;16(11):703-710

[5]Madsen C, Würtzen G, Carstensen J. Short-term toxicity study in rats dosed with menthone. Toxicol Lett. 1986 Jul-Aug;32(1-2):147-52

Menthone/薄荷酮 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.48mL

1.30mL

0.65mL

32.41mL

6.48mL

3.24mL

64.83mL

12.97mL

6.48mL

Menthone/薄荷酮 技术信息

CAS号10458-14-7
分子式C10H18O
分子量 154.25
SMILES Code O=C1C(C(C)C)CCC(C)C1
MDL No. MFCD00062998
别名 孟酮 ;p-Menthan-3-one; NSC 9280; NSC 113134
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

溶解方案

DMSO: 105 mg/mL(680.71 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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