Activating transcription factor 6 (ATF-6) is one of the three main endoplasmic reticulum(ER) transmembrane sensors that elicit the unfolded protein response(UPR). Melatonin (N-acetyl-5-methoxytryptamine), produced in the human pineal gland during the night phase of the light-dark cycle, plays important roles in physiological and pharmacological functions and also acts as a novel selective ATF-6 inhibitor. Melatonin treatment (10-5 mM) for 24 h after pretreatment by tunicamycin inhibited the expression COX-2 by downregulating ATF-6, which increased the apoptosis of HepG2 cells via CHOP and Bcl-2/Bax pathway[4]. Melatonin was an effective free radical scavenger and antioxidant which reduced amyloid β protein toxicity of Alzheimer’s disease, reduced oxidative damage in several models of Parkinson’s disease, protected against glutamate excitotoxicity, reduced ischemia-reperfusion injury, lowered neural damage due to d-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxins. It also had been shown to reduce lipid peroxidation and oxidative damage to nuclear DNA[5].
Melatonin/褪黑素 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
CHO cells
Function assay
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells, Ki=8.00E-05 μM
9435890
CHO-Galpha16 cells
Function assay
20 mins
Binding affinity to rat MT1 receptor expressed in CHO-Galpha16 cells assessed as Ca2+ mobilization after 20 mins by FLIPR assay, EC50=0.56 nM
21237644
CHOK1
Function assay
3 h
Displacement of [125I]2-iodomelatonin from human recombinant melatonin receptor 1 expressed in CHOK1 cells after 3 hrs, IC50=0.21 nM
23403082
HEK293 cells
Function assay
Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand), Ki=0.2 nM
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells, Ki=8.00E-05 μM
9435890
CHO-Galpha16 cells
Function assay
20 mins
Binding affinity to rat MT1 receptor expressed in CHO-Galpha16 cells assessed as Ca2+ mobilization after 20 mins by FLIPR assay, EC50=0.56 nM
21237644
CHOK1
Function assay
3 h
Displacement of [125I]2-iodomelatonin from human recombinant melatonin receptor 1 expressed in CHOK1 cells after 3 hrs, IC50=0.21 nM
23403082
HEK293 cells
Function assay
Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand), Ki=0.2 nM
11063602
NIH 3T3 cells
Function assay
Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay, Ki=0.66 nM
10737738
NIH3T3 cells
Function assay
Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells, Ki=0.4 nM
14643330
NIH3T3 cells
Function assay
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells, Ki=0.3 nM
14643330
NIH3T3 cells
Function assay
90 mins
Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in rat NIH3T3 cells after 90 mins, Ki=0.263 nM
22047556
NIH3T3 cells
Function assay
90 mins
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in rat NIH3T3 cells after 90 mins, Ki=0.339 nM
22047556
SH-SY5Y cells
10 μM
Function assay
24 h
Neuroprotective activity against H2O2-induced oxidative stress-associated death in human SH-SY5Y cells assessed as increase in cell viability at 10 uM incubated for 24 hrs prior to H2O2 challenge measured after 24 hrs by MTT assay
United States, Oregon
... 展开 >>
Oregon Health and Science University
Recruiting
3181 SW Sam Jackson Park Road, Oregon, United States, 97239
Contact: Amber Laurie 866-424-6060 sleeplab@ohsu.edu 收起 <<
United States, California
... 展开 >>
University of California, San Diego
Recruiting
San Diego, California, United States, 92093
Contact: Naomi Deacon, Ph.D. 619-471-9484 ndeacon@ucsd.edu
Contact: Pamela De Young (858) 246-2154 sleepresearch@ucsd.edu
Principal Investigator: Atul Malhotra, MD
Sub-Investigator: Naomi Deacon, Ph.D. 收起 <<
United States, California
... 展开 >>
Pain Medicine Center
Recruiting
San Diego, California, United States, 92134
Contact: Ian M Fowler, MD 619-532-8943 ian.m.fowler.mil@mail.mil 收起 <<
United States, Pennsylvania
... 展开 >>
Duquesne University School of Pharmacy Center for Pharmacy Care
Pittsburgh, Pennsylvania, United States, 15282 收起 <<
United States, California
... 展开 >>
UCLA Headache Research and Treatment Program
Los Angeles, California, United States, 90077
UCSF Pediatric Brain Center
San Francisco, California, United States, 94158 收起 <<
United States, California
... 展开 >>
University of California, San Diego
Recruiting
San Diego, California, United States, 92093
Contact: Robert Owens, MD rowens@ucsd.edu
Principal Investigator: Robert Owens, MD 收起 <<
Egypt
... 展开 >> Tanta University, Faculty of Medicine
Recruiting
Tanta, Egypt
Contact: Azza Kamal Al-shahawy, Professor of pediatrics azzaalshahawy@gmail.com 收起 <<
France
... 展开 >> Hôpital Femme Mere Enfant
Recruiting
Bron, France, 69677
Contact: Patricia Franco, MD patricia.franco@chu-lyon.fr
Principal Investigator: Patricia Franco, MD
CHU de Caen
Not yet recruiting
Caen, France, 14033
Contact: Fabien Guenole, MD guenole-f@chu-caen.fr
Principal Investigator: Fabien Guenole, MD
Centre Hospitalier du Chinonais
Recruiting
Chinon, France
Contact: TRIPI GABRIELE
Principal Investigator: TRIPI GABRIELE, MD
CHRU de Strasbourg
Not yet recruiting
Strasbourg, France, 67091
Contact: Carmen Schroder, MD shroderc@unistra.fr
Principal Investigator: Carmen Schroder, MD
CHU de Tours
Recruiting
Tours, France, 37044
Contact: Frédérique Bonnet-Brilhault, MD
Principal Investigator: Frédérique Bonnet-Brilhault, MD 收起 <<
India
... 展开 >> All India Institute of Medical Sciences (AIIMS)
Recruiting
Bhubaneswar, Odisha, India, 751019
Contact: RITUPARNA MAITI, MD 9438884191 rituparnamaiti@gmail.com
Contact: BISWA R MISHRA, MD brm1678@gmail.com 收起 <<
United States, California
... 展开 >>
University of California, San Francisco, (UCSF)
Recruiting
San Francisco, California, United States, 94158
Contact: Amy A. Gelfand, M.D. 415-885-7832 Amy.Gelfand@ucsf.edu
Contact: Laura Dapkus, NCPT 415-860-2202 Laura.Dapkus@ucsf.edu 收起 <<
Canada, Ontario
... 展开 >>
Centre for Addiction and Mental Health
Recruiting
Toronto, Ontario, Canada, M5S 1S8
Principal Investigator: Bernard Le Foll, MD, PhD
Center for Addiction and Mental Health
Recruiting
Toronto, Ontario, Canada, M5S 2S1
Contact: Bernard Le Foll, MD, PhD 416-535-8501 ext 34772 bernard.lefoll@camh.ca 收起 <<
France
... 展开 >> Service de Psychiatrie de l'Enfant et de l'Adolescent - Hôpital de la Pitié-Salpêtrière
Paris, France, 75013
Centre Hospitalier Spécialisé Henri Laborit
Poitiers, France, 86280
Service de Psychothérapie de l'Enfant et de l'Adolescent - Hôpital Robert Debré
Reims, France, 51092
Pôle de Psychiatrie de l'Enfant et de l'Adolescent - Centre Hospitalier Guillaume Régnier
Rennes, France, 35200 收起 <<
Canada, Ontario
... 展开 >>
Mount Sinai Hospital
Recruiting
Toronto, Ontario, Canada, M5G1X5
Contact: Lisa Burry, PharmD lisa.burry@sinaihealthsystem.ca
Principal Investigator: Lisa Burry
Sunnybrook Health Sciences Centre
Recruiting
Toronto, Ontario, Canada
Contact: Damon Scales damon.scales@sunnybrook.ca
Principal Investigator: Damon Scales, MD PhD
Principal Investigator: Louise Rose, PhD
Canada, Quebec
Hôpital du Sacré-Coeur
Not yet recruiting
Montréal, Quebec, Canada
Contact: David Williamson david.williamson@umontreal.ca
Principal Investigator: David Williamson, PhD
Principal Investigator: Francis Bernard, MD 收起 <<
United States, Georgia
... 展开 >>
Emory University
Recruiting
Atlanta, Georgia, United States, 30322
Principal Investigator: Paul D Terry, PhD, MPH
Consultative Gastroenterology
Recruiting
Atlanta, Georgia, United States
Principal Investigator: Paul Terry, PhD 收起 <<
United States, Tennessee
... 展开 >>
Southeast Renal Research Institute
Recruiting
Chattanooga, Tennessee, United States, 37408
Contact: James A Tumlin, MD 423-826-8003 jamestumlinmd@nephassociates.com
Contact: Jeremy Whitson 423-826-8003 jeremywhitson@nephassociates.com
Principal Investigator: James A Tumlin, MD 收起 <<
Spain
... 展开 >> Hospital Clínico Universitario Lozano Blesa
Not yet recruiting
Zaragoza, Spain, 50009
Contact: Francisco A. García-Gil, Physician 0034976765700 agarciagil@telefonica.net
Principal Investigator: Francisco A. García-Gil, Physician 收起 <<
Switzerland
... 展开 >> Institution de Lavigny
Not yet recruiting
Lavigny, Vaud, Switzerland, 1175
Contact: Giovanni B. Foletti, Dr, MD, MER ++ 41 21 821 46 46 giovanni.foletti@ilavigny.ch
Contact: Noëlle I. Mercier, Dr. ++ 41 21 821 41 11 noelle.mercier@ilavigny.ch
Principal Investigator: Giovanni B. Foletti, Dr, MD, MER
Sub-Investigator: Sforza Emilia, Dr. , MD
Sub-Investigator: Noëlle Mercier, Dr. 收起 <<
Sleep Deprivation
... 展开 >> Intensive Care Psychosis 收起 <<
Phase 3
Not yet recruiting
November 15, 2019
Lebanon
... 展开 >> Hotel Dieu de France
Not yet recruiting
Beirut, Lebanon
Contact: Moussa A Riachy, MD +9613361672
Sub-Investigator: Ihab Ibrahim, MD
Principal Investigator: Moussa A Riachy, MD
Sub-Investigator: Samer W Najem, MD
Sub-Investigator: Aline Hajj, PharmD 收起 <<
Canada, Alberta
... 展开 >>
Alberta Children's Hospital
Recruiting
Calgary, Alberta, Canada, T3B 6A8
Contact: Victor Lewis, MD 403-955-7237 victor.lewis@albertahealthservices.ca
Principal Investigator: Victor Lewis, MD
Canada, British Columbia
Children's & Women's Health Centre of British Columbia
Recruiting
Vancouver, British Columbia, Canada, V6H 3V4
Contact: Rod Rassekh, MD 604-875-2644 rrassekh@cw.bc.ca
Principal Investigator: Rod Rassekh, MD
Canada, Ontario
Children's Hospital of Eastern Ontario
Recruiting
Ottawa, Ontario, Canada, K1H 8L1
Contact: Donna Johnston, MD 613-737-7600 ext 2751 djohnston@cheo.on.ca
Principal Investigator: Donna Johnston, MD
The Hospital for Sick Children
Recruiting
Toronto, Ontario, Canada, M5G 1X8
Contact: Sylvain Baruchel, MD 416-813-7795 sylvain.baruchel@sickkids.ca
Principal Investigator: Sylvain Baruchel, MD
Canada, Quebec
CHU Ste-Justine
Recruiting
Montreal, Quebec, Canada, H3T 1C5
Contact: Yvan Samson, MD 514-345-4969 yvan.samson@umontreal.ca
Principal Investigator: Yvan Samson, MD 收起 <<
Brazil
... 展开 >> CEDOES - Centro de Diagnóstico e Pesquisa da Osteoporose do Espirito Santo.
Recruiting
Vitória, Espírito Santo, Brazil, 29055-450
Contact: Karina Oliveira
Hospital de Clínicas de Porto Alegre
Recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
Contact: Denis Martinez
Allergisa Pesquisa Dermato Cosmética Ltda.
Recruiting
Campinas, São Paulo, Brazil
Contact: Mauro Crippa Jr. +55 19 3789-8615
Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto USP
Recruiting
Ribeirão Preto, São Paulo, Brazil, 14048-900
Contact: Alan Eckeli
Centro de Estudos Multidisciplinar CEPES da Faculdade de Medicina do ABC
Recruiting
Santo André, São Paulo, Brazil
Contact: Rosa Hasan +55 11 4993-5459
Dr Consulta Clinica Medica Ltda
Recruiting
São Paulo, Brazil, 01141-020
Contact: Tatiana Hirakawa
Centro Paulista de Investigação Clínica e Serviços Médicos Ltda.
Terminated
São Paulo, Brazil, 04266-010
Centro de Desenvolvimento em Estudo Clínicos Brasil - CDEC Brasil
Recruiting
São Paulo, Brazil
Contact: Dalva Poyares +55 11 5579 0373 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Contact: Ki-Young Jung, professor +82-2-2072-0694 jungky10@gmail.com 收起 <<
France
... 展开 >> Institut de Cancérologie de l'ouest - Site Paul Papin
Not yet recruiting
Angers, France, 49000
Contact: Sophie ABADIE-LACOURTOISIE, MD
CHU Besançon
Not yet recruiting
Besançon, France, 25000
Contact: Alexandre KALISKI, MD
CHU Clermont-Ferrand
Active, not recruiting
Clermont-Ferrand, France, 63003
Centre Jean Perrin
Recruiting
Clermont-Ferrand, France, 63011
Contact: Xavier DURANDO, MD
Principal Investigator: Xavier DURANDO, MD
Centre Léon-Bérard
Active, not recruiting
Lyon, France, 69008
Centre Antoine Lacassagne
Not yet recruiting
Nice, France, 06100
Contact: Véronique MARI, MD
Institut de Cancérologie de l'ouest - Site René Gauducheau
Not yet recruiting
Saint Herblain, France, 44805
Contact: Emmanuelle BOURBOULOUX, MD
Hôpital Paul-Brousse
Not yet recruiting
Villejuif, France, 94800
Contact: Pasquale INNOMINATO, MD 收起 <<
United States, Massachusetts
... 展开 >>
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215 收起 <<
United States, Colorado
... 展开 >>
Parkview Medical Center
Recruiting
Pueblo, Colorado, United States, 81003
Contact: Mike Forte, DO 719-564-1542 mike_forte@parkviewmc.com
Contact: Josh Gordon, DO 7195641542 joshiah_gordon@parkviewmc.com 收起 <<
Brazil
... 展开 >> Hospital de Clinicas de Porto Alegre
Recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
Contact: Maria Helena P Rigatto, Professor +5551992460185 mhprigatto@gmail.com
Pontificia Universidade Católica do Rio Grande do Sul
Recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 90619-900
Contact: Maria Helena P Rigatto, Professor +555133203000 ext 2288 mhprigatto@gmail.com 收起 <<
United States, California
... 展开 >>
UCLA Headache Research and Treatment Program
Recruiting
Los Angeles, California, United States, 90077
Contact: Andrew Charles, M.D. 415-885-7832 ACharles@mednet.ucla.edu
Contact: Laura Dapkus, NCPT 415-885-7832 Laura.Dapkus@ucsf.edu
University of California, San Francisco, (UCSF)
Recruiting
San Francisco, California, United States, 94158
Contact: Amy A. Gelfand, M.D. 415-885-7832 Amy.Gelfand@ucsf.edu
Contact: Laura Dapkus, NCPT 415-860-2202 Laura.Dapkus@ucsf.edu 收起 <<
United States, Arkansas
... 展开 >>
Hot Springs, Arkansas, United States
United States, California
Los Angeles, California, United States
San Diego, California, United States
United States, Florida
Miami, Florida, United States
United States, Georgia
Atlanta, Georgia, United States
Macon, Georgia, United States
United States, Indiana
Danville, Indiana, United States
United States, Kansas
Overland Park, Kansas, United States
United States, Louisiana
Metairie, Louisiana, United States
United States, Maryland
Chevy Chase, Maryland, United States
United States, Nevada
Las Vegas, Nevada, United States
United States, Ohio
Dublin, Ohio, United States
United States, South Carolina
Columbia, South Carolina, United States 收起 <<
Hong Kong
... 展开 >> Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong
Recruiting
Hong Kong, Hong Kong
Contact: Jihui Zhang, PhD 收起 <<
United States, Massachusetts
... 展开 >>
Vanda Investigational Site
Boston, Massachusetts, United States
United States, Michigan
Vanda Investigational Site
Detroit, Michigan, United States 收起 <<
United States, California
... 展开 >>
VA Palo Alto Health Care System
Recruiting
Palo Alto, California, United States, 94304
Principal Investigator: Jamie M Zeitzer, PhD 收起 <<
United States, Hawaii
... 展开 >>
University of Hawaii at Manoa, John A. Burns School of Medicine, Dept. of Complementary and Alternative Medicine
Honolulu, Hawaii, United States, 96813 收起 <<
Canada, Nova Scotia
... 展开 >>
Dalhousie University
Not yet recruiting
Halifax, Nova Scotia, Canada, B3H 2R1
Contact: Sydney Dale-McGrath, MA 902-494-5177 bnbdndd@dal.ca
Principal Investigator: Penny Corkum, PhD
Principal Investigator: Shelly Weiss, MD 收起 <<
United States, New York
... 展开 >>
Depression Evaluation Service - New York State Psychiatric Institute
Recruiting
New York, New York, United States, 10032
Contact: Jonathan W. Stewart, M.D. 646-774-8070 jws6@cumc.columbia.edu
Contact: David Hellerstein, M.D. 646-774-8069 hellers@nyspi.columbia.edu
Principal Investigator: Jonathan W. Stewart, M.D.
Sub-Investigator: David Hellerstein, M.D. 收起 <<
United States, New York
... 展开 >>
Icahn School of Medicine at Mount Sinai
Recruiting
New York, New York, United States, 10029
Contact: Ariella Hoffman-Peterson, BA 212-659-5525 ariella.hoffman-peterson@mssm.edu
Principal Investigator: William H. Redd, Ph.D. 收起 <<
United States, Maryland
... 展开 >>
Johns Hopkins Bayview Medical Center
Recruiting
Baltimore, Maryland, United States, 21224
Contact: Kori Kindbom, MA 410-550-0197 kindbom@jhmi.edu
Contact: Karin J Neufeld, MD MPH 410-550-0197 kneufel2@jhmi.edu 收起 <<
United States, Rhode Island
... 展开 >>
Miriam Hospital Women's Medicine Collaborative
Recruiting
Providence, Rhode Island, United States, 02904
Sub-Investigator: Teri Pearlstein, MD 收起 <<
United States, Illinois
... 展开 >>
Northwestern University
Recruiting
Chicago, Illinois, United States, 60611
Principal Investigator: Aleksandar Videnovic, MD 收起 <<
United States, Illinois
... 展开 >>
Northwestern Memorial Hospital
Recruiting
Chicago, Illinois, United States, 60611
Contact: Kristen Knutson, PhD 312-503-1526 kristen.knutson@northwestern.edu
Principal Investigator: Kristen Knutson, PhD 收起 <<
United States, Colorado
... 展开 >>
University of Colorado Anschutz Medical Campus/Children's Hospital Colorado
Aurora, Colorado, United States, 80045 收起 <<
Italy
... 展开 >> AO San Paolo - Polo Universitario
Recruiting
Milano, Italy, 20142
Contact: Giovanni Mistraletti, MD +39.339.8245014 giovanni.mistraletti@unimi.it 收起 <<
United States, California
... 展开 >>
UCSD Medical Center, Hillcrest
Recruiting
San Diego, California, United States, 92103
Contact: Diane L Sorenson, MPH 619-543-5575 dsorenson@ucsd.edu
Contact: Luis F Martinez, B.A. 619-507-1182 lfmartinez@ucsd.edu
Principal Investigator: Barbara L Parry, M.D.
Sub-Investigator: Charles J Meliska, Ph.D.
Sub-Investigator: Richard Hauger, M.D.
Sub-Investigator: Shah Golshan, Ph.D. 收起 <<
United States, California
... 展开 >>
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
Recruiting
Los Angeles, California, United States, 90024
Contact: Christine Shim, BA 310-237-8431 cmshim@mednet.ucla.edu 收起 <<
United States, Connecticut
... 展开 >>
Department of Psychology, Wesleyan University
Middletown, Connecticut, United States, 06459
United States, New York
Columbia Presbyterian Medical Center
New York, New York, United States, 10032 收起 <<
Sleep Initiation and Maintenan... 展开 >>ce Disorders 收起 <<
Phase 3
Completed
-
Korea, Republic of
... 展开 >>
Dankook University Hospital
Cheonan, Chungcheongnam, Korea, Republic of, 330-715
Seoul National University Bundang Hospital
Sungnam, Gyeonggi, Korea, Republic of, 463-707
St. Vincent Hospital
Suwon, Gyeonggi, Korea, Republic of, 442-723
Kangwon National University Hospital
Chuncheon, Kangwon, Korea, Republic of, 200-722
Keimyung University, Dongsan Medical Center
Daegu, Korea, Republic of, 700-712
Chonnam National University Hospital
Gwangju, Korea, Republic of, 501-757
St. Paul's Hospital
Seoul, Korea, Republic of, 130-709
Kyung Hee University Hospital at Gangdong
Seoul, Korea, Republic of, 134-727
Asan Medical Center
Seoul, Korea, Republic of, 138-736
Konkuk University Medical Center
Seoul, Korea, Republic of, 143-729 收起 <<
United States, Pennsylvania
... 展开 >>
Center for Interdisciplinary Research on Nicotine Addiction, School of Medicine, University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 收起 <<
United States, New York
... 展开 >>
Beth Israel Medical Center
Recruiting
New York, New York, United States, 10003
Contact: Marie Grippo 212-420-2704 mgrippo@chpnet.org
Principal Investigator: Joanne Loewy, DA 收起 <<
United States, California
... 展开 >>
Pacific Research Network
San Diego, California, United States, 92103
United States, Florida
MD Clinical
Hallandale Beach, Florida, United States, 33009
Miami research Associates
South Miami, Florida, United States, 33143
United States, Georgia
Sleep Disorders Centers of Georgia
Atlanta, Georgia, United States, 30342
United States, Illinois
Chicago Research Center
Chicago, Illinois, United States, 60634
United States, Kansas
Vince & Associates Clinical Research
Overland Park, Kansas, United States, 66212
United States, Kentucky
Community Research and Sleep Management
Crestview Hills, Kentucky, United States, 41017
United States, Maryland
Center for Sleep and Wake Disorders
Chevy Chase, Maryland, United States, 20815
United States, New York
Clinilabs, Inc.
New York, New York, United States, 10119 收起 <<
United States, Florida
... 展开 >>
Tampa General Hospital
Recruiting
Tampa, Florida, United States, 33606
Contact: Linda Odibo lodibo@health.usf.edu
Contact: Judette M Louis, MD 8132598500 jlouis1@health.usf.edu 收起 <<
Sleep Initiation and Maintenan... 展开 >>ce Disorders 收起 <<
Phase 3
Completed
-
Korea, Republic of
... 展开 >>
St. Vincent Hospital
Suwon, Gyeonggi, Korea, Republic of, 442-723
St. Paul's Hospital
Seoul, Korea, Republic of, 130-709
Kyung Hee University Hospital at Gangdong
Seoul, Korea, Republic of, 134-727
Konkuk University Medical Center
Seoul, Korea, Republic of, 143-729 收起 <<
United States, Virginia
... 展开 >>
Fort Belvoir Community Hospital
Recruiting
Fort Belvoir, Virginia, United States, 22060
Contact: Svetlana R Ho 571-231-2936 svetlana.r.ho.ctr@mail.mil
Principal Investigator: John K Werner, MD, PhD 收起 <<
Sweden
... 展开 >> Department of Neuroscience, Uppsala University
Recruiting
Uppsala, Sweden, 75324
Contact: Jonathan Cedernaes, MD, PhD +46184714102 jonathan.cedernaes@neuro.uu.se
Contact: Christian Benedict, PhD 46184714136 christian.benedict@neuro.uu.se
Principal Investigator: Jonathan Cedernaes, MD, PhD 收起 <<
United States, Florida
... 展开 >>
Miami, Florida, United States
Pembroke Pines, Florida, United States
United States, Hawaii
Honolulu, Hawaii, United States
United States, New York
New York, New York, United States 收起 <<
United States, Colorado
... 展开 >>
University of Colorado Anschutz Medical Campus
Recruiting
Aurora, Colorado, United States, 80045
Contact: Josiane Broussard sleep.study@colorado.edu 收起 <<
Germany
... 展开 >> Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow - Klinikum, Charité- Universitätsmedizin
Berlin, Germany, 13353 收起 <<
United States, New York
... 展开 >>
New York Obesity Nutrition Research Center
Not yet recruiting
New York, New York, United States, 10032
Contact: Theresa Pizinger, MS 212-851-5583 tmp2125@cumc.columbia.edu
Contact: Ismel Salazar, MS 212-851-5578 is2527@cumc.columbia.edu
Principal Investigator: Marie-Pierre St-Onge, PhD 收起 <<
Germany
... 展开 >> Goethe University Hospital Frankfurt, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, and Department of Psychiatry, Psychosomatic Medicine and Psychotherapy
Recruiting
Frankfurt am Main, Germany
Contact: Mayer jutta.mayer@kgu.de
Contact: Freitag C.Freitag@em.uni-frankfurt.de
Netherlands
Radboud University Medical Centre, Karakter Child and Adolescent Psychiatry, and Department of Psychiatry
Not yet recruiting
Nijmegen, Netherlands
Contact: de Ruiter Saskia.deRuiter@radboudumc.nl
Contact: Buitelaar Jan.Buitelaar@radboudumc.nl
Spain
Vall d'Hebron Research Institute, Group of Psychiatry, Mental Health and Addiction
Recruiting
Barcelona, Spain
Contact: Ibáñez poliba83@gmail.com
Contact: Ramos-Quiroga jaramos@vhebron.net
United Kingdom
King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience
Recruiting
London, United Kingdom
Contact: Rommel anna.rommel@kcl.ac.uk
Contact: Kuntsi jonna.kuntsi@kcl.ac.uk 收起 <<
Germany
... 展开 >> Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow - Klinikum, Charité- Universitätsmedizin
Berlin, Germany, 13353 收起 <<
United States, New Hampshire
... 展开 >>
Dartmouth Hitchcock Medical Center
Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Mardi A Crane, PhD 603-653-9972 margaret.a.crane@dartmouth.edu
Contact: Peter Peter 603-653-9972 peter.payne@dartmouth.edu 收起 <<
United States, California
... 展开 >>
Sansum Diabetes Research Institute
Not yet recruiting
Santa Barbara, California, United States, 93105
Contact: Wendy C Bevier, Ph.D. 805-682-7638 ext 207 wbevier@sansum.org
Contact: Arianna Larez 805-335-0124
United States, Hawaii
inControl Diabetes Center
Not yet recruiting
Honolulu, Hawaii, United States, 96814 收起 <<
United States, Oregon
... 展开 >>
Oregon Health & Science University
Not yet recruiting
Portland, Oregon, United States, 97239
Contact: Nicole P Bowles, PhD 503-494-2541 bowlesn@ohsu.edu 收起 <<
United States, Indiana
... 展开 >>
Purdue University
Recruiting
West Lafayette, Indiana, United States, 47907
Contact: Jan Green 765-496-6342 jkgreen@purdue.edu 收起 <<
United States, Florida
... 展开 >>
QPS-MRA, LLC (Miami Research Associates)
South Miami, Florida, United States, 33143
Qps-Mra, Llc
South Miami, Florida, United States, 33143 收起 <<
Russian Federation
... 展开 >>
State research center of preventive medicine
Moscow, Russian Federation, 101000
Research and Education Center of Moscow State University named after M.V. Lomonosov
Moscow, Russian Federation, 119192
First Moscow State Medical University
Moscow, Russian Federation, 119435 收起 <<
United States, Arizona
... 展开 >>
University of Arizona Dept of Psychiatry Research facilities
Recruiting
Tucson, Arizona, United States, 85724
Contact: Jo-Ann Gehrels 520-626-0105 jgehrels@psychiatry.arizona.edu 收起 <<
Israel
... 展开 >> The Institute for Sleep and Fatigue Medicine, Sheba Medical Center
Recruiting
Tel Hashomer, Israel
Contact: Julia Tamir, MA 972-54-4811146 julia.tamir@sheba.health.gov.il 收起 <<
Japan
... 展开 >> Yoyogi Sleep Disorder Clinic, Foundation of Sleep and Health Science
Recruiting
Shibuya-ku, Tokyo, Japan, 151-0053
Contact: Akira Usui, MD 收起 <<
United States, California
... 展开 >>
Children's Hospital of Los Angeles
Recruiting
Los Angeles, California, United States, 90027
Contact: Joyce Sutedja 323-361-6219 jsutedja@chla.usc.edu 收起 <<
United States, New York
... 展开 >>
Stony Brook University
Recruiting
Stony Brook, New York, United States, 11794
Contact: Diana Kaell 631-444-7832 diana.kaell@stonybrookmedicine.edu
Principal Investigator: Jill Miller-Horn, MD, MS
Principal Investigator: Dennis Choi, MD, PhD 收起 <<
United States, New Jersey
... 展开 >>
Englewood Hospital and Medical Center
Recruiting
Englewood, New Jersey, United States, 07631
Contact: Jeff Smok, MD jeff.smok@ehmchealth.org
Contact: Jamie Ketas jamie.ketas@ehmchealth.org
Principal Investigator: Jeff Smok, MD
Sub-Investigator: Margit Kaufman, MD 收起 <<
United States, New York
... 展开 >>
Columbia University
New York, New York, United States, 10032
United States, Oregon
Oregon Health & Sciences University
Portland, Oregon, United States, 97239
United States, Texas
Baylor College of Medicine
Houston, Texas, United States, 77030 收起 <<
Denmark
... 展开 >> Department of Surgical Gastroenterology, University Hospital of Copenhagen in Gentofte
Not yet recruiting
Hellerup, Denmark, 2900
Contact: Bülent Kücükakin +45 3997824 bulkuc01@gentoftehosp.kbhamt.dk 收起 <<
United States, California
... 展开 >>
Collaborative Neuroscience Network, Inc.
Garden Grove, California, United States, 92845
Synergy Research Centers
San Diego, California, United States, 91950
United States, Georgia
Atlanta Institute of Medicine & Research, Inc.
Altanta, Georgia, United States, 30328
United States, Maryland
Capital Clinical Research Associates
Rockville, Maryland, United States, 20852
United States, Ohio
NorthCoast Clinical Trials
Beachwood, Ohio, United States, 44122
United States, Pennsylvania
CRI Worldwide
Philadelphia, Pennsylvania, United States, 19139
United States, Texas
FutureSearch Clinical Trials, L.P.
Austin, Texas, United States, 78756
FutureSearch Trials of Dallas, L.P.
Dallas, Texas, United States, 75231
Claghorn-Lesem Research Clinic, Ltd.
Houston, Texas, United States, 77008 收起 <<
Brazil
... 展开 >> Hospital de Clínicas de Porto Alegre
Recruiting
Porto Alegre, RS, Brazil, 900035-903
Contact: Simone de Azevedo Zanette, MD 555133598430
Principal Investigator: Wolnei Caumo, PhD 收起 <<
Critically Ill Adult Patients ... 展开 >>in Intensive Care Units 收起 <<
Not Applicable
Completed
-
Korea, Republic of
... 展开 >>
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, Korea, Republic of, 03722 收起 <<
United States, Nebraska
... 展开 >>
University of Nebraska Medical Center, Center for Nursing Science
Recruiting
Omaha, Nebraska, United States, 68198-5330
Contact: Alyson E Hanish, PhD, MSN, RN 402-559-6731 alyson.hanish@unmc.edu
Principal Investigator: Alyson E Hanish, PhD, MSN, RN
Sub-Investigator: Danielle J Stappert, BSN, RN
Sub-Investigator: Abbey J Klein, BSN, RN 收起 <<
Italy
... 展开 >> Department of Experimental Medicine
Recruiting
Rome, Italy, 00161
Contact: Andrea M Isidori, MD, PhD +390649970540 andrea.isidori@uniroma1.it 收起 <<
United States, Colorado
... 展开 >>
Sleep and Chronobiology Laboratory
Recruiting
Boulder, Colorado, United States, 80309
Principal Investigator: Kenneth P. Wright, PhD 收起 <<
United States, Florida
... 展开 >>
Meridien Research
Brooksville, Florida, United States, 34601
Meridien Research
Saint Petersburg, Florida, United States, 33709
United States, New Jersey
Exodon LLC
Mount Arlington, New Jersey, United States, 07856
United States, Pennsylvania
Scranton Medical Institute
Scranton, Pennsylvania, United States, 18503
Israel
Merchav clinics
Tel-Aviv, Israel
United Kingdom
CPS Research
Glasgow, United Kingdom, G20 0XA 收起 <<
Germany
... 展开 >> University Medical Center Aachen
Aachen, North Rhine-Westphalia, Germany, 52074
CTC North GmbH & Co. KG
Hamburg, Germany, 20246
Italy
Department of Systems Medicine
Rome, Lazio, Italy, 00133 收起 <<
United States, California
... 展开 >>
Keck School of Medicine, Clinical Trials Unit at Keck Medical Center of USC
Los Angeles, California, United States, 90033 收起 <<
搜索
