Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. Meclocycline Sulfosalicylate is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris[1]. Meclocycline is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically[2]. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses[3]. Meclocycline can produce significant protection of C. elegans from delayed death. Four of the compounds were tested in an ex vivo mouse heart ischemia/reperfusion model and two, meclocycline and 3-amino-1,2,4-triazole, significantly reduced infarction size[4].
Meclocycline Sulfosalicylate Salt/甲环素磺基水杨酸盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
32D cl 3 cells
1 µM，10 µM，100 µM
1 hour
To test the radiation protection and damage mitigation capacity of Meclocycline on 32D cl 3 cells. Results showed no significant effect on cell survival post-irradiation at 1 µM concentration.
In Vivo. 2010 Jan-Feb;24(1):9-19
C. elegans strain gc47;gcSi4
100μM
96 hours
To evaluate the protective effect of Meclocycline against delayed hypoxic injury, results showed that Meclocycline significantly reduced delayed death in C. elegans.
PLoS One. 2017 Apr 20;12(4):e0176061
Meclocycline Sulfosalicylate Salt/甲环素磺基水杨酸盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice (C57/Bl6)
Langendorff-perfused heart model
Perfusion
20μM
Continuous administration 30 minutes before ischemia and throughout 60 minutes of reperfusion
To evaluate the protective effect of Meclocycline against cardiac ischemia/reperfusion injury, results showed that Meclocycline significantly reduced infarction size.
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