There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
MST-312, also called Telomerase inhibitor IX, is a synthetic compound that acts as a reversible TERT (telomerase) inhibitor, and is described to be more potent than epigallocatechin gallate.
MST-312 induced cytotoxicity in a dose-dependent manner with IC50 of 3.6 µM.
Transl Oncol. 2023 Jan;27:101569
OVCAR3 (ovarian adenocarcinoma cell line)
0.01–50 µM
72 hours
MST-312 induced cytotoxicity in a dose-dependent manner with IC50 of 7.1 µM.
Transl Oncol. 2023 Jan;27:101569
A2780 (ovarian adenocarcinoma cell line)
0.01–50 µM
72 hours
MST-312 induced cytotoxicity in a dose-dependent manner with IC50 of 3.9 µM.
Transl Oncol. 2023 Jan;27:101569
PA-1 (ovarian teratocarcinoma cell line)
0.01–50 µM
72 hours
MST-312 induced cytotoxicity in a dose-dependent manner with IC50 of 4.2 µM.
Transl Oncol. 2023 Jan;27:101569
H1299 cells
0.25 μM
120 hours
MST312 significantly inhibited H1299 cell proliferation, with ALDH+ cells being more sensitive than ALDH- cells.
Mol Cancer. 2011 Aug 9;10:96
H460 cells
1 μM
120 hours
MST312 exhibited a dose-dependent antiproliferative effect on H460 cells, with ALDH+ cells being more sensitive than ALDH- cells.
Mol Cancer. 2011 Aug 9;10:96
MDA-MB-435
0.23 μM (IC50)
24 hours
To investigate the inhibitory effect of MST-312 on telomerase activity and its impact on cancer cell survival. Results showed that MST-312 inhibited telomerase activity in a concentration-dependent manner with an IC50 of 0.23 μM.
Eur J Med Chem. 2017 Jan 5;125:117-129
primary ependymoma cells
0 to 4 μM
72 hours
To evaluate the effect of MST-312 on cell viability. Results showed a significant decrease in cell number (P<0.001), increased DNA damage (γH2AX expression, P<0.01), decreased proliferative index (MIB-1, P<0.01), and increased apoptosis in some cells (cleaved caspase 3).
Brain Pathol. 2010 Jul;20(4):780-6
NCI-H441 cells
2.5 μM
28 days
Induced cellular senescence and increased secretion of pro-inflammatory cytokines
Respir Res. 2011 Jun 10;12(1):78
Leishmania major promastigote cells
0.1 to 4 µM
30 minutes
To test the effect of human telomerase inhibitors on L. major telomerase activity. Both MST-312 and TMPyP4 effectively inhibited L. major telomerase activity, with MST-312 being more potent, achieving complete inhibition at 0.5µM, which is eight times lower than the concentration required for TMPyP4.
Microorganisms. 2025 Feb 7;13(2):357
FLO-1 cells
1 μM
10 days
To evaluate the antiproliferative effect of MST-312 analog GRN163L on H460 cells, results showed that SFN enhanced the activity of GRN163L.
Transl Oncol. 2010 Dec 1;3(6):389-99
HEp-2 cells
20-100 μM
18 hours
MST-312 inhibits HSV-1 replication, reduces viral protein accumulation.
J Virol. 2015 Oct;89(19):9804-16
hTERT-HME1 cells
20-100 μM
18 hours
MST-312 inhibits HSV-1 replication, reduces cytopathic effects and viral protein accumulation.
J Virol. 2015 Oct;89(19):9804-16
MST-312 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Athymic mice
H460 xenograft model
Intraperitoneal injection
40 mg/kg
Once daily for 25 days
MST312 significantly reduced tumor volume (70% reduction), decreased the number of ALDH+ CSCs, and induced apoptosis.
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