There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
G protein-coupled receptor 119 (GPR119), a class A G protein-coupled receptor (GPCR), is involved in regulating metabolic homoeostasis, with GPR119 agonists targeted for the treatment of type-2 diabetes and obesity. MBX-2982 is a selective, orally-available GPR119 agonist. In cells pretreated with MBX-2982 (1 μM) in “chronic incubation/washout” experiments, cAMP accumulation was significantly increased compared to control cells and the sustained response after “chronic incubation/washout” was high at 84.62 ± 20.22% of acute response. In GLUTag cells, MBX-2982 (1 μM; 120 min) evoked a statistically significant increase in GLP-1 secretion compared to control cells[3]. In C57BL/6 mice, MBX-2982 at a dose of 10 mg/kg increased the plasma GLP-1 levels without a glucose load[4].
MBX-2982 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HepG2 cells
1-10 μM
24 h
MBX-2982 inhibited sorafenib-induced LC3B II protein expression, indicating suppression of autophagosome formation.
J Exp Clin Cancer Res. 2018 Nov 29;37(1):295.
MDA-MB-231 cells
1-10 μM
24 h
MBX-2982 inhibited gefitinib-induced LC3B II protein expression, indicating suppression of autophagosome formation.
J Exp Clin Cancer Res. 2018 Nov 29;37(1):295.
MCF-7 cells
1-10 μM
24 h
MBX-2982 inhibited gefitinib-induced LC3B II protein expression, indicating suppression of autophagosome formation.
J Exp Clin Cancer Res. 2018 Nov 29;37(1):295.
HEK293 cells
10^−5M-10^−11M
30 min
Measure cAMP accumulation to evaluate the activation of GPR119 by MBX-2982
Nat Commun. 2022 Nov 17;13(1):7033.
MBX-2982 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Balb/c-nu mice
MCF-7 xenograft model
Oral
10 mg/kg
5 times a week for 40 days
Combination of MBX-2982 with gefitinib significantly inhibited the growth of MCF-7 xenograft tumors.
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