Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 囊泡
/
G蛋白偶联受体/G蛋白
小分子阳性药 神经信号通路 内分泌学/激素 外泌体
/
阿片受体
神经递质
/ Loperamide HCl/洛哌丁胺盐酸盐

Loperamide HCl/洛哌丁胺盐酸盐 {[allProObj[0].p_purity_real_show]}

货号：A171923 同义名： 盐酸洛哌丁胺 / R-18553 hydrochloride; Loperamide(hydrochloride)

Loperamide HCl是一种强效且选择性的μ-阿片受体激动剂。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Loperamide HCl/洛哌丁胺盐酸盐 化学结构 CAS号：34552-83-5
Loperamide HCl/洛哌丁胺盐酸盐 化学结构
CAS号：34552-83-5
Loperamide HCl/洛哌丁胺盐酸盐 3D分子结构
CAS号：34552-83-5
Loperamide HCl/洛哌丁胺盐酸盐 化学结构 CAS号：34552-83-5
Loperamide HCl/洛哌丁胺盐酸盐 3D分子结构 CAS号：34552-83-5
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Loperamide HCl/洛哌丁胺盐酸盐 纯度/质量文件 产品仅供科研

货号：A171923 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 Opioid receptor ↓ ORL1 ↓ μ-opioid receptor ↓ 其他靶点 纯度
Racecadotril ✔ 98%
JTC-801 ++

Opioid receptor-like1 (ORL1), IC50: 94 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Loperamide HCl/洛哌丁胺盐酸盐 生物活性

描述 Loperamide (Hydrochloride) is an opioid receptor agonist widely used for the treatment of diarrhea[3]. In contrast with other opioid agonists, loperamide is a peripherally acting μ-receptor agonist exerting its effects mainly on the myenteric plexus of the gastrointestinal longitudinal muscle layer. It decreases peristalsis and fluid secretion resulting in longer gastrointestinal transit time. The bioavailability of the drug is extremely low. Moreover, it is actively excluded from the central nervous system; hence, it lacks the central effects of euphoria and analgesia at the recommended dosages[4]. Rats were orally gavaged with 1.5, 3, or 6 mg/kg body weight (BW) of loperamide hydrochloride for 7 days. The results after 7 days administration of loperamide, revealed dose-dependent increase in aspartate aminotransferase, lactate dehydrogenase, creatine kinase-MB, and serum concentration of cardiac troponin I, total homocysteine, and nitric oxide. Loperamide provoked cardiotoxicity through oxidative stress, lipid peroxidation, and DNA fragmentation in rats[5]. Loperamide decreased cell viability in a dose-dependent fashion and was most effective against canine osteosarcoma cells. When co-incubated with doxorubicin, loperamide induced a synergistic cell kill in canine carcinoma cells[6].

Loperamide HCl/洛哌丁胺盐酸盐 细胞实验

Cell Line
Concentration Treated Time Description References
L-mdr1a 2 μM 4 hours Loperamide was very effectively transported by the mouse mdr1a P-GP J Clin Invest. 1996 Jun 1;97(11):2517-24.
L-MDR1 2 μM 4 hours Loperamide was very effectively transported by the human MDR1 P-GP J Clin Invest. 1996 Jun 1;97(11):2517-24.
LLC-PK1 2 μM 4 hours Loperamide was very effectively transported by both the MDR1 and the mdr1a P-GP J Clin Invest. 1996 Jun 1;97(11):2517-24.
Pituitary GH4C1 cells 30 μM Loperamide augments intracellular calcium levels after activation of SOC channels. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.
RBL-2H3 mast cells 30 μM Loperamide augments intracellular calcium levels after activation of SOC channels. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.
Smooth muscle DDT-MF2 cells 30 μM Loperamide augments intracellular calcium levels after activation of SOC channels. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.
Astrocytoma 1321N cells 30 μM Loperamide augments intracellular calcium levels after activation of SOC channels and also causes elevation in calcium levels in the absence of SOC channel activation. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.
NIH 3T3 fibroblasts 30 μM Loperamide augments intracellular calcium levels after activation of SOC channels. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.
HL-60 leukemic cells 10–30 μM Loperamide augments intracellular calcium levels when SOC channels are activated but has no effect when SOC channels are not activated. 1997 Dec 23;94(26):14912-7. doi: 10.1073/pnas.94.26.14912.

Loperamide HCl/洛哌丁胺盐酸盐 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Mdr1a (−/−) mice Oral 1 mg/kg Single dose, analyzed after 4 hours Loperamide showed a marked 13.5-fold increase in brain radioactivity levels in mdr1a (?/?) mice, indicating that mdr1a P-GP in the blood-brain barrier restricts loperamide entry J Clin Invest. 1996 Jun 1;97(11):2517-24.
Mice 5xFAD transgenic mice Oral 5 mg/kg body weight Once per week for 4 weeks To evaluate the effects of loperamide-induced slow gut transit on Alzheimer's disease pathology. Results showed that loperamide treatment increased amyloid-beta and microglia levels in the brain and altered the transcription of genes related to norepinephrine secretion and immune responses in colonic tissue. J Adv Res. 2024 Nov;65:283-295
ICR CD1 mice CFA-induced inflammatory pain model Intrathecal injection, intraplantar injection, subcutaneous injection 0.01–1 nmol (intrathecal), 4.6 nmol (intraplantar), 0.8 mg/kg (subcutaneous) Single administration, behavioral tests performed 15 min (intraplantar) or 45 min (subcutaneous) post-injection To evaluate the synergistic analgesic effects of loperamide-oxymorphindole combination in inflammatory pain. Results demonstrated significant synergy (10-150-fold ED50 reduction) across spinal, peripheral and systemic routes, mediated by peripheral μ- and δ-opioid receptors. Anesthesiology. 2019 Sep;131(3):649-663
Transgenic CF mice CF mouse model Inhalation 1 mmol/l Single dose, two minutes duration Loperamide inhibits sodium ion absorption in the airway epithelium of CF mice with a longer duration of action than amiloride. Thorax. 1996 Dec;51(12):1229-32

Loperamide HCl/洛哌丁胺盐酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03575078 Lymphoma Phase 1 Not yet recruiting August 23, 2023 -
NCT00555620 - Completed - -
NCT02677844 - Completed - -

Loperamide HCl/洛哌丁胺盐酸盐 参考文献

[1]Hanauer SB. The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord. 2008 Winter;8(1):15-20.

[2]Litovitz T, Clancy C, et al. Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol. 1997;35(1):11-9.

[3]Wu PE, Juurlink DN. Clinical Review: Loperamide Toxicity. Ann Emerg Med. 2017 Aug;70(2):245-252

[4]Akel T, Bekheit S. Loperamide cardiotoxicity: "A Brief Review". Ann Noninvasive Electrocardiol. 2018 Mar;23(2):e12505

[5]Olofinsan KA, Ajala-Lawal RA, Ajiboye TO. Loperamide-induced cardiotoxicity in rats: Evidence from cardiac and oxidative stress biomarkers. J Biochem Mol Toxicol. 2019 Apr;33(4):e22278

[6]Regan RC, Gogal RM Jr, Barber JP, Tuckfield RC, Howerth EW, Lawrence JA. Cytotoxic effects of loperamide hydrochloride on canine cancer cells. J Vet Med Sci. 2014 Dec;76(12):1563-8

Loperamide HCl/洛哌丁胺盐酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.74mL

1.95mL

0.97mL

19.47mL

3.89mL

1.95mL

Loperamide HCl/洛哌丁胺盐酸盐 技术信息

CAS号34552-83-5
分子式C29H34Cl2N2O2
分子量 513.5
SMILES Code O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.[H]Cl
MDL No. MFCD00058581
别名 盐酸洛哌丁胺 ;R-18553 hydrochloride; Loperamide(hydrochloride); R 18553; PJ 185; NSC 696356; Loperamide hydrochloride; R-18553(hydrochloride)
运输蓝冰
InChI Key PGYPOBZJRVSMDS-UHFFFAOYSA-N
Pubchem ID 71420
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, room temperature
溶解方案

DMSO: 50 mg/mL(97.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(1.95 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Loperamide | 34552-83-5 | R-18553 | R18553 | R 18553 | Opioid Receptor Agonist | GPCR/G Protein | Neuronal Signaling | Autophagy | Opioid Receptor | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Loperamide HCl/洛哌丁胺盐酸盐 纯度/质量文件 | Loperamide HCl/洛哌丁胺盐酸盐 亚型比较 | Loperamide HCl/洛哌丁胺盐酸盐 生物活性 | Loperamide HCl/洛哌丁胺盐酸盐 临床数据 | Loperamide HCl/洛哌丁胺盐酸盐 参考文献 | Loperamide HCl/洛哌丁胺盐酸盐 实验方案 | Loperamide HCl/洛哌丁胺盐酸盐 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z