Lisinopri dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. Lisinopril is the only ACE inhibitor that exhibits a linear dose-response curve. Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[3]. In all concentrations (25, 75 and 250 mg/l drinking water), lisinopril significantly increased PRA (plasma renin) and decreased ACE activities. Arterial blood pressure was decreased only in the group receiving high lisinopril concentration (Controls 119+/-10.27, Ld3 98+/-5.4 mm Hg)[4]. Systolic blood pressure (SBP) was normal in Wistar rats, SHR (spontaneously hypertensive rats) expressed hypertension and lisinopril normalized the SBP. Lisinopril normalized the increase in SBP and partly reversed the alterations of anxiety-like behaviour in SHR[5].
Lisinopril Dihydrate/赖诺普利二水合物 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Peritoneal-derived macrophages
1 μM
24 h
To evaluate the effect of Lisinopril on the phagocytosis of Aβ42 fibrils by wild-type macrophages. Results showed that Lisinopril significantly reduced the phagocytic ability of wild-type macrophages for Aβ42 fibrils.
Brain. 2020 Jan 1;143(1):336-358.
Lisinopril Dihydrate/赖诺普利二水合物 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Duchenne muscular dystrophy model
Drinking water
10 mg/kg/day lisinopril and 37.5 mg/kg/day spironolactone
Starting at 4 or 8 weeks of age, continued until 20 weeks of age
Early treatment significantly improved cardiac and skeletal muscle function, reduced cardiomyocyte damage and fibrosis.
Circulation. 2011 Aug 2;124(5):582-8
Mice
Chronic hypoxia model
Intramuscular injection
1 μg
3-5 dpi
To study the effect of ACE inhibitor Lisinopril on muscle regeneration under chronic hypoxia, results showed Lisinopril increased MuSCs proliferation and muscle regeneration
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