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Linezolid/利奈唑胺 {[allProObj[0].p_purity_real_show]}

货号:A360550 同义名: 利奈唑胺 / PNU-100766

Linezolid是一种合成的首选类噁唑烷酮类抗生素,对大多数革兰氏阳性菌有效。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Linezolid/利奈唑胺 化学结构 CAS号:165800-03-3
Linezolid/利奈唑胺 化学结构
CAS号:165800-03-3
Linezolid/利奈唑胺 3D分子结构
CAS号:165800-03-3
Linezolid/利奈唑胺 化学结构 CAS号:165800-03-3
Linezolid/利奈唑胺 3D分子结构 CAS号:165800-03-3
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Linezolid/利奈唑胺 纯度/质量文件 产品仅供科研

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Linezolid/利奈唑胺 生物活性

描述 Linezolid is the first of a new class of antibacterial drugs, the oxazolidinones. It has inhibitory activity against a broad range of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), glycopeptide-intermediate S. aureus (GISA), vancomycin-resistant enterococci (VRE) and penicillin-resistant Streptococcus pneumoniae. The drug also shows activity against certain anaerobes, including Clostridium perfringens, C. difficile, Peptostreptococcus spp. and Bacteroidesfragilis[3]. Linezolid is bacteriostatic against most susceptible organisms but displays bactericidal activity against some strains of pneumococci, Bacteroides fragilis and C. perfringens. Moreover, linezolid 600 mg twice daily produced >85% clinical/microbiological cure in vancomycin-resistant enterococcal infections[4]. Linezolid inhibits bacterial growth by targeting bacterial ribosomes and by interfering with bacterial protein synthesis. Lactic acidosis is a rare, but potentially lethal, side effect of linezolid[5]. In addition, the incidence of vomiting, diarrhea, and thrombocytopenia in patients treated with linezolid is significantly higher than that with other treatments. Linezolid seems to be more effective than vancomycin for treating people with SSTIs (skin and soft tissue infections) [6].

Linezolid/利奈唑胺 参考文献

[1]Swaney SM, Aoki H, et al. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria. Antimicrob Agents Chemother. 1998 Dec;42(12):3251-5.

[2]Shinabarger DL, Marotti KR, et al. Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents Chemother. 1997 Oct;41(10):2132-6.

[3]Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections [published correction appears in Drugs. 2003;63(19):2126]. Drugs. 2001;61(4):525–551

[4]Clemett D, Markham A. Linezolid. Drugs. 2000;59(4):815–828

[5]Santini A, Ronchi D, Garbellini M, Piga D, Protti A. Linezolid-induced lactic acidosis: the thin line between bacterial and mitochondrial ribosomes. Expert Opin Drug Saf. 2017;16(7):833–843

[6]Li Y, Xu W. Efficacy and safety of linezolid compared with other treatments for skin and soft tissue infections: a meta-analysis. Biosci Rep. 2018;38(1):BSR20171125. Published 2018 Feb 13

Linezolid/利奈唑胺 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.82mL

2.96mL

1.48mL

29.64mL

5.93mL

2.96mL

Linezolid/利奈唑胺 技术信息

CAS号165800-03-3
分子式C16H20FN3O4
分子量 337.35
SMILES Code CC(NC[C@H]1CN(C2=CC=C(N3CCOCC3)C(F)=C2)C(O1)=O)=O
MDL No. MFCD00937825
别名 利奈唑胺 ;PNU-100766
运输蓝冰
InChI Key TYZROVQLWOKYKF-ZDUSSCGKSA-N
Pubchem ID 441401
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, sealed in dry, room temperature

溶解方案

DMSO: 105 mg/mL(311.25 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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