Laninamivir (R 125489) exhibits potent inhibition of influenza neuraminidase (NA), demonstrating IC50 values of 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1), and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
体外研究
Laninamivir (R 125489) effectively inhibits common oseltamivir-resistant viruses, including those carrying the His274Tyr substitution [1].
Laninamivir (R 125489) demonstrates potent activity against p57N2, p09N1, and N5 with a binding mode similar to Zanamivir [1].
Laninamivir/拉尼那米韦 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDCK cells
1 to 5 μM
three passages
screened and identified substitutions conferring resistance to laninamivir
J Virol. 2019 Mar 5;93(6):e01825-18
MDCK cells
0.06–1 µM
3 days
Evaluation of the inhibitory effect of Laninamivir combined with Baloxavir on H3N2 virus, showing strong synergy (268.57 µM2%)
Viruses. 2024 Sep 14;16(9):1467
MDCK cells
0.06–1 µM
3 days
Evaluation of the inhibitory effect of Laninamivir combined with Baloxavir on H1N1-PR8-R292K mutant strain, showing moderate synergy (72.3 µM2%)
Viruses. 2024 Sep 14;16(9):1467
MDCK cells
0.06–1 µM
3 days
Evaluation of the inhibitory effect of Laninamivir combined with Baloxavir on H1N1-WSN-I38T mutant strain, showing moderate synergy (52.02 µM2%)
Viruses. 2024 Sep 14;16(9):1467
MDCK cells
0.06–1 µM
3 days
Evaluation of the inhibitory effect of Laninamivir combined with Baloxavir on H1N1-PR8-I38T mutant strain, showing strong synergy (294.33 µM2%)
Viruses. 2024 Sep 14;16(9):1467
Laninamivir/拉尼那米韦 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c mice
Influenza virus infection model
Intranasal administration
10 mg/kg
Single dose
Evaluate the therapeutic efficacy of Laninamivir in influenza virus-infected mice, showing significant reduction in weight loss, mortality, and lung viral titers.
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