Kuromanin, a natural product isolated and purified from the herbs of Chrysanthemum indicum, has been shown to improve blood glucose concentrations and lipid homeostasis and to reduce obesity.
Kuromanin chloride/矢车菊素-3-O-葡萄糖苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
PC12 neuronal cells
50–200 µg/mL
one week
To evaluate the effects of MNCM extract on neurite outgrowth. Results showed that MNCM extract stimulated neurite outgrowth in a dose-dependent manner.
Molecules. 2020 Apr 16;25(8):1837
NIH 3T3 MDR1
50-150 μM
25 minutes
Kuromanin increased the basal ATPase activity of Pgp and decreased the verapamil-stimulated ATPase activity.
Pharmaceutics. 2021 Dec 2;13(12):2062
human monocyte-derived dendritic cells (MDDCs)
100 μM
20 hours
Inhibition of CD38 enzymatic activity, reduction of RSV-induced inflammatory responses and oxidative stress
Immunology. 2018 May;154(1):122-131
HepG2 hepatocytes
10 µM
2 h pretreatment followed by 24 h co-treatment with oleic acid
Evaluate the protective effects of Kuromanin against oleic acid-induced steatosis. Results showed Kuromanin significantly inhibited intracellular lipid accumulation (42-58% reduction) but did not protect mitochondrial membrane potential (MMP) or ATP stores.
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