There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity[3]. Incubation of 10 micromol/L KN-93 induced the cell growth reduction in a time-dependent manner from 78.27% at 8 h to 11.48% at 48 h. However, KN-92, an inactive derivative of KN-93, did not inhibit cell proliferation effectively[4]. Inhibition of Ca2+/calmodulin kinase (KN-63, KN-92; 5 microM) reduced Cl--conductance in 50% of the cells investigated without affecting [Ca2+]i[5]. The CaMKII inhibitor, KN-93 (N-[2-(N-(4-Chlorocinnamyl)-N-methylaminomethyl)phenyl]-N-[2-hydroxyethyl]-4-methoxybenzenesulfonamide), but not the inactive isomer, KN-92 (2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, phosphate), blocked clozapine's augmenting effect on NMDA-evoked responses in pyramidal cells of the rat mPFC. KN-93 also inhibited the facilitatory effect of clozapine on electrically evoked responses in the pyramidal cells, while KN-92 did not show any effect[6].
KN-92 phosphate 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rabbit ventricular myocytes
1 μmol/l
KN-92 had no effect on hypokalemia-induced EADs
Circulation. 2015 Oct 20;132(16):1528-1537.
Rabbit ventricular myocytes
1 μM
7.5 ± 1.2 minutes
KN-92, an inactive analog of KN-93, failed to prevent H2O2-induced EADs
Circ Res. 2009 Jan 2;104(1):79-86.
Head kidney macrophages (HKM)
20 μM
24 hours
As a structural analogue of KN-93, KN-92 lacks CaM kinase inhibitory activity and is used as an experimental control.
PLoS Pathog. 2014 Apr 24;10(4):e1004018.
HeLa cells
5 μM
30 minutes
Used as an inactive control for KN-93 to study the effect of CaMKII inhibitors on ERK/MAPK cascade activation
Proc Natl Acad Sci U S A. 2005 May 24;102(21):7577-82.
Hippocampal neurons
2 μM
24 hours
KN-92, as an inactive analog of KN-93, was used in control experiments, showing that KN-92 did not affect the increase in GluA1 levels
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):828-33.
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