Administered 30 min prior to each SKF81297 injection, observed for 45 min
Evaluate the effects of JMV-2959 on seizures in the D1R-mediated kindling model, showing no differences in seizure severity and number.
Int J Mol Sci. 2019 May 20;20(10):2480
Rats
Conditioned place preference (CPP), intravenous self-administration (IVSA), and behavioral stimulation models
Intraperitoneal injection
1 or 3 mg/kg
Single or repeated administration, lasting for 8 days (CPP) or 3 days (IVSA)
JMV2959 significantly and dose-dependently reduced THC-induced conditioned place preference and behavioral stimulation, as well as WIN55,212-2 intravenous self-administration and relapse-like behavior
Int J Mol Sci. 2021 Feb 27;22(5):2397
Rats
Conditioned place preference (CPP) and intravenous self-administration (IVSA) models
Intraperitoneal injection
1, 3, and 6 mg/kg
Single or multiple administrations, experiments conducted 20 minutes after each administration
JMV2959 significantly reduced methamphetamine-induced conditioned place preference (CPP) expression and decreased methamphetamine intravenous self-administration (IVSA) and relapse-like behavior.
Int J Mol Sci. 2018 Sep 26;19(10):2925
Rats
Opioid-induced changes in dopamine, endocannabinoids, and GABA concentrations in the nucleus accumbens shell model
Intraperitoneal, VTA injection, or NAC perfusion
3 mg/kg (i.p.) or 2 µg/10 µg (VTA) or 8 mM/40 mM (NAC perfusion)
Single administration, monitored for 3 hours
JMV2959 pre-treatment significantly reversed fentanyl-induced anandamide increases in the NACSh, resulting in a significant AEA decrease and intensified fentanyl-induced decreases in accumbens 2-AG levels, while also reducing fentanyl-evoked GABA efflux and behavioral stimulation.
Int J Mol Sci. 2017 Nov 22;18(11):2486
Rat
Wistar rats
Intraperitoneal injection
3 mg/kg
Single administration
To investigate the effects of JMV2959 on WIN55,212-2-induced behavioral stimulation and dopamine release in the nucleus accumbens. Results showed that JMV2959 significantly reduced WIN55,212-2-induced behavioral stimulation and dopamine release in the nucleus accumbens.
Int J Mol Sci. 2020 Dec 28;22(1):210
Mice and rats
Alcohol dependence models
Intraperitoneal injection
9 mg/kg (mice) and 1, 2, 4 mg/kg (rats)
Once daily for 5 days (mice) and twice weekly for 7 days (rats)
JMV2959 reduced ethanol intake but did not affect ethanol preference. In rats, JMV2959 reduced operant self-administration of both ethanol and sucrose.
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