Isosakuranetin, a natural product isolated and purified from the fruits of Citrus aurantium L. with cytotoxic and fungicide properties and produces significant decrease in blood pressure.
Isosakuranetin/异野樱素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human islets
5 μmol/L
1 hour
Abolished PM5S-enhanced GSIS
Diabetes. 2022 Apr 1;71(4):837-852
Mouse islets
5 μmol/L
1 hour
Inhibited insulin secretion at high glucose concentrations and abolished PM5S-enhanced GSIS
Diabetes. 2022 Apr 1;71(4):837-852
human dorsal root ganglion (hDRG) neurons
10 μM
inhibition of PS-induced responses
Br J Pharmacol. 2020 Jun;177(12):2683-2695
human stem cell-derived sensory (hSCDS) neurons
5 μM
inhibition of PS-induced calcium responses
Br J Pharmacol. 2020 Jun;177(12):2683-2695
S. aureus USA300
0-64 μg/mL
18 hours
To evaluate the effect of Isosakuranetin on biofilm formation by S. aureus. Results showed that Isosakuranetin significantly inhibited biofilm formation.
Virulence. 2023 Dec;14(1):2260675
A549 cells
0-64 μg/mL
2 hours
To evaluate the effect of Isosakuranetin on the ability of S. aureus to invade A549 cells. Results showed that Isosakuranetin significantly reduced the number of bacteria invading the cells.
Virulence. 2023 Dec;14(1):2260675
human keratinocyte HaCaT cells
10, 20, 50 μM
24 hours
Inhibited UV-B-induced MMP-1 expression via suppression of ERK1/2 kinase pathways
Int J Mol Sci. 2016 Sep 1;17(9):1449
Isosakuranetin/异野樱素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
N-dimethylnitrosamine-induced liver cirrhosis model
Oral
15 mg/kg
Daily for six weeks
To evaluate the effects of ISN on the pharmacokinetics of tofacitinib in rats with N-dimethylnitrosamine-induced liver cirrhosis (LC). Results showed that ISN treatment significantly decreased the total area under the plasma concentration–time curves (AUC) of tofacitinib in LC rats and restored the expression of CYP3A1/2 and CYP2C11 in the liver and intestine.
Pharmaceutics. 2022 Dec 1;14(12):2684
Mice
Acute oxaliplatin-induced neuropathic pain model
Intraperitoneal injection
2 mg/kg
Single dose
To evaluate the effect of isosakuranetin on oxaliplatin-induced cold and mechanical hypersensitivity. Results showed that isosakuranetin significantly reduced cold and mechanical hypersensitivity.
Pain. 2023 Sep 1;164(9):2060-2069
C57BL/6J male mice
S. aureus-induced pneumonia model
Subcutaneous injection
50 mg/kg
Every 12 hours for 96 hours
To evaluate the therapeutic effect of Isosakuranetin in a mouse model of S. aureus-induced pneumonia. Results showed that Isosakuranetin significantly improved survival rates, reduced lung damage, and decreased levels of inflammatory cytokines.
Virulence. 2023 Dec;14(1):2260675
Mice
Chronic constriction injury (CCI) model
Intraperitoneal injection
2 mg/kg
Single injection
To evaluate the role of Isosakuranetin in nerve injury-induced neuropathic pain, showing it alleviates heat hypersensitivity in wild-type but not in TRPM3?/? mice
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