Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor. 10 μM of Isoquercitrin of the seven compounds (myricitrin, isoquercitrin, hypoletin-7-O-β-D-xylopyranoside, quercitrin, kaempferin, kaempferol, and amentoflavone) partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG. Furthermore, isoquercitrin potently attenuated the lipid peroxidation of rat brain homogenates initiated by nitric oxide, with an IC(50) value of 1.04 μM[3]. Isoquercitrin was effective in alleviating soleus muscle mass loss following denervation in a dose-dependent manner (the optimal protective effect at 20 mg/kg/d). Isoquercitrin may alleviate soleus muscle atrophy and mitophagy and reverse the slow-to-fast fiber type conversion following denervation via inhibition of oxidative stress and inflammatory response[4]. Treatment with ISO (Isoquercitrin) largely rescues STZ(streptozotocin)-induced differentiation inhibition and enhances neurite outgrowth of Neuro2a (N2a) cells in vitro. Moreover, oral administration of ISO protects hippocampal neurons from STZ-induced neurotoxicity and significantly improves the cognitive and behavioural impairment in STZ-induced AD rats[5]. Isoquercitrin is also effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies[6].
Isoquercitrin/异槲皮苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
YOM36 yeast
1, 10, 30 μM
Extended the chronological lifespans of YOM36 yeasts
Antioxidants (Basel). 2023 Oct 31;12(11):1939
BY4741 yeast
1, 10, 30 μM
24 h
Improved survival rate of yeast under H2O2 stimulation
Antioxidants (Basel). 2023 Oct 31;12(11):1939
K6001 yeast
0.3, 1, 3, 10, 30, 100 μM
Extended the replicative lifespans of K6001 yeasts
Antioxidants (Basel). 2023 Oct 31;12(11):1939
SK-N-SH cells
10 and 20 µM
48 hours
To evaluate the antiviral effect of isoquercitrin on HSV-1 infection, results showed that isoquercitrin significantly inhibited HSV-1 GFP expression.
Antioxidants (Basel). 2021 Oct 18;10(10):1638
Human umbilical vein endothelial cells (HUVECs)
10, 50, 100 µM
48 hours
To evaluate the protective effect of isoquercitrin against high glucose-induced endothelial apoptosis. Results showed that isoquercitrin significantly attenuated HG-induced endothelial apoptosis by reducing TUNEL-positive cells, modulating mitochondrial membrane potential, decreasing the expression of pro-apoptotic proteins Bax and c-caspase3, and increasing the expression of anti-apoptotic protein Bcl-2.
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