To investigate the effects of ipriflavone on GAG loss and HA molecular weight in bovine cartilage explants under IL-1β stimulation. Results showed that ipriflavone reduced GAG losses and increased the molecular weight of HA.
Int J Mol Sci. 2023 Aug 4;24(15):12422
Fibroblast-like synoviocytes (FLS)
2 μM, 10 μM
24 hours
Ipriflavone increased HA accumulation and suppressed MMP1 and MMP3 expression in TNF-α-stimulated FLS.
Int J Mol Sci. 2022 Apr 7;23(8):4089
Rat chondrosarcoma (RCS) cells
1 μM, 5 μM, 10 μM, 20 μM
24 hours
Ipriflavone significantly restored the Alcian blue staining of RCS-KIAA cells, dose-dependently increased extracellular matrix formation, and reduced HA leakage into the culture medium.
Int J Mol Sci. 2022 Apr 7;23(8):4089
Primary tubular epithelial cells (PTCs)
200 nM
Upregulated DHHC9 expression, downregulated β-catenin levels, and inhibited TGF-β1-induced fibronectin (FN) production
Arthritis Res Ther. 2019 May 2;21(1):109
Primary neurons
5–20 μM
IP suppressed tau hyperphosphorylation via GR/PI3K/AKT/GSK3β pathway
Aging Cell. 2022 Mar;21(3):e13572
Human periodontal ligament cells (hPDLCs)
10^-7 M
24, 48, 72 hours
Promote proliferation and osteogenic differentiation of hPDLCs
Drug Des Devel Ther. 2018 Jan 11;12:137-148
Ipriflavone/依普黄酮 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Male Sprague Dawley rats
Dexamethasone-induced osteoporotic animal model
Oral gavage
50 mg/kg
Daily administration for 8 weeks
To evaluate the therapeutic effect of Ipriflavone on dexamethasone-induced osteoporosis. Results showed that Ipriflavone significantly increased bone mineral density and bone mineral content, reduced bone resorption markers (such as TRAP and ACP), and improved bone histomorphology.
Antioxidants (Basel). 2022 Mar 6;11(3):508
C57BL/6J mice
Destabilization of the medial meniscus (DMM)-induced osteoarthritis model
Oral
200 mg/kg/day
Daily administration for 4, 6, 8, 10 weeks
To evaluate the effects of ipriflavone on DMM-induced osteoarthritis in mice. Results showed that ipriflavone significantly reduced the Mankin score, decreased KIAA1199 expression, and preserved HA stainability.
Int J Mol Sci. 2023 Aug 4;24(15):12422
DBA/1 J mice
Collagen-induced arthritis (CIA) mouse model
Oral
100 mg/kg, 200 mg/kg
Once daily for 3 weeks
Ipriflavone significantly improved the symptoms and reduced the serum concentrations of HA in CIA mice.
Int J Mol Sci. 2022 Apr 7;23(8):4089
Mice
STZ-induced diabetic mice and HFD/STZ-induced diabetic mice
20 and 40 mg/kg
IP ameliorated diabetic cognitive impairment by antagonizing GR, including tau hyperphosphorylation, synaptic impairment, and neuroinflammation
Aging Cell. 2022 Mar;21(3):e13572
Wistar rats
Orthodontic tooth movement (OTM) model
Intragastric administration
10 mg/kg/day
Once daily for 10 days
Promote periodontal tissue remodeling and bone formation
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