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描述 | Iohexol is a non-ionic, water-soluble contrast agent used primarily as a reference marker to assess glomerular filtration rate (GFR) in renal function studies. It is also employed in various imaging procedures, such as myelography, computerized tomography (including cisternography and ventriculography), and MicroCT imaging[1].[2]. |
体内研究 | When administered orally at 0.25-4 mL/kg on a weekly basis, iohexol enhances the differentiation of intestinal segments in dogs, particularly after doses ranging from 0.5 to 2.0 mL/kg[4]. Iohexol administered intravenously at a dose of 64.7 mg/kg is utilized to measure the glomerular filtration rate (GFR) in both healthy dogs and those with chronic kidney disease (CKD)[5]. |
体外研究 | Iohexol at a concentration of 150 mg I/mL over a 0-24 hour period reduces cell viability in NRK 52-E cells[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00658359 | Kidney Transplantation | Phase 2 | Completed | - | - |
NCT00554450 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... 展开 >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Florida Elite Research Institute Miami, Florida, United States, 33169 United States, Minnesota Prism Research St. Paul, Minnesota, United States, 55114 United States, Texas Dgd Research, Inc. San Antonio, Texas, United States, 78229 收起 << |
NCT03453775 | Low Back Pain ... 展开 >> Sciatica Disc, Herniated Foraminal Hernia Lumbar Foraminal Stenosis Chronic Low Back Pain Pain, Chronic Injection Site Infiltration 收起 << | Not Applicable | Recruiting | May 30, 2018 | Belgium ... 展开 >> Hopital Erasme Recruiting Anderlecht, Bruxelles, Belgium, 1070 Contact +3225553111 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.22mL 0.24mL 0.12mL |
6.09mL 1.22mL 0.61mL |
12.18mL 2.44mL 1.22mL |
CAS号 | 66108-95-0 |
分子式 | C19H26I3N3O9 |
分子量 | 821.14 |
SMILES Code | O=C(C1=C(I)C(N(C(C)=O)CC(O)CO)=C(I)C(C(NCC(O)CO)=O)=C1I)NCC(O)CO |
MDL No. | MFCD00077732 |
别名 | |
运输 | 蓝冰 |
InChI Key | NTHXOOBQLCIOLC-UHFFFAOYSA-N |
Pubchem ID | 3730 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, sealed in dry, room temperature |
溶解方案 |
DMSO: 50 mg/mL(60.89 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(60.89 mM) 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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