There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Indoleamine 2,3-dioxygenase (IDO) is one of the key heme-containing dioxygenases that catalyze the rate limiting step in the catabolism of the essential amino acid tryptophan to N-formylkynurenine by oxidative cleavage of the indole 2,3 double bond[2]. IDO-IN-1 is an IDO inhibitor with IC50 of 59 nM[3]. C57BL/6 mice bearing GMCSF-secreting B16 tumors were subcutaneously administered with IDO-IN-1 at 25, 50, and 75 mg/kg b.i.d. and 50% tumor growth inhibition was observed at 75 mg/kg[3].
作用机制
IDO-IN-1 bounds to IDO through the oxygen of the hydroxyamidine to the iron of the heme in the ferrous state.
搜索
HazMat Fee +
