Hyaluronic acid (HA) is prominently utilized in aesthetic medicine for its capability to bind with a multitude of water molecules, thereby enhancing tissue hydration and resistance to mechanical damage. HA plays critical roles in various biological processes including wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It has also been investigated in clinical trials for its potential applications in identifying tumor markers, treating liver diseases, and developing pharmaceuticals[1]. Hyaluronan significantly influences cancer development and metastasis. The interaction between HA and HA fragments with tumor cells initiates downstream signaling pathways, fostering cell proliferation, adhesion, migration, and invasion. Additionally, this interaction induces angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like properties, and resistance to chemotherapy and radiotherapy, particularly in gastrointestinal cancers[2].
体外研究
Hyaluronic acid (HA) is prominently utilized in aesthetic medicine for its capability to bind with a multitude of water molecules, thereby enhancing tissue hydration and resistance to mechanical damage. HA plays critical roles in various biological processes including wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It has also been investigated in clinical trials for its potential applications in identifying tumor markers, treating liver diseases, and developing pharmaceuticals[1].
Hyaluronan significantly influences cancer development and metastasis. The interaction between HA and HA fragments with tumor cells initiates downstream signaling pathways, fostering cell proliferation, adhesion, migration, and invasion. Additionally, this interaction induces angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like properties, and resistance to chemotherapy and radiotherapy, particularly in gastrointestinal cancers[2].
Assess cytotoxicity, results showed no cytotoxic effect
Adv Sci (Weinh). 2022 Feb;9(4):e2103189.
HT-29 cells
0.1, 1, 10, 50, 100 μg/mL
24 h
Assess cytotoxicity, results showed no cytotoxic effect
Adv Sci (Weinh). 2022 Feb;9(4):e2103189.
Caco-2 cells
0.1, 1, 10, 50, 100 μg/mL
24 h
Assess cytotoxicity, results showed no cytotoxic effect
Adv Sci (Weinh). 2022 Feb;9(4):e2103189.
SK-N-SH cells
0.3 mg/mL
2 weeks
To investigate the effect of low-molecular-weight hyaluronic acid (LMWHA) on the differentiation of SK-N-SH cells into PDLSC-like cells. Results showed that LMWHA significantly upregulated the expression of PDL-related genes.
Cells. 2023 Nov 30;12(23):2743.
Peritoneal macrophages
250 μg/mL and 500 μg/mL
24 h
To evaluate the effect of o-HA on macrophage migration and invasion, results showed that o-HA significantly enhanced macrophage migration and invasion
Theranostics. 2019 Mar 16;9(7):1980-1992.
Hyaluronic acid/透明质酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
DSS-induced acute colitis model
Rectal administration
30 mg/kg
Administered on days 0, 2, 4, duration of 12 days
Evaluate therapeutic efficacy of HA-enema in DSS-induced colitis, results showed HA-enema significantly reduced inflammation, decreased intestinal permeability, and protected gut barrier integrity
Adv Sci (Weinh). 2022 Feb;9(4):e2103189.
C57BL/6 male mice
Myocardial infarction model
Intravenous injection
5 mg/kg
Every other day for 28 days
To evaluate the therapeutic effect of o-HA on myocardial infarction, results showed that o-HA reduced infarct size and promoted myocardial function reconstruction and angiogenesis
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