货号:A2925448
同义名:
重组人VSIG4蛋白(C-Fc, HEK293)
/ Recombinant Human VSIG4 (C-Fc, HEK293); V-set and immunoglobulin domain-containing protein 4
Recombinant Human VSIG4 (C-Fc, HEK293) 是人源VSIG4蛋白,在HEK293细胞中表达,带有C端Fc标签。该蛋白是一种跨膜免疫调节蛋白,结构与B7家族相关,可结合补体片段C3b和iC3b,是T细胞增殖和IL-2产生的强效负调控因子,同时抑制补体旁路途径转化酶,主要高表达于肺、胎盘及静息巨噬细胞中。


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| 描述 | V-set and immunoglobulin domain-containing protein 4(VSIG4) is a transmembrane protein contains a signal peptide, a V-type Ig-like domain, a C2-type Ig-like domain, several potential O-glycosylation sites, and an intracellular domain with 2 potential phosphorylation sites and is structurally related to the B7 family of immune regulatory proteins. This protein is also a receptor for the complement component 3 fragments C3b and iC3b.The main function is strong negative regulator of T-cell proliferation and IL2 production and it is also potent inhibitor of the alternative complement pathway convertases. It abundantly expressed in several fetal tissues such as adult tissues, highest expression in lung and placenta and it also expressed in resting macrophages. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Arg20-Val284 |
| 蛋白编号 | Q9Y279 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 56.3 KDa |
| SMILES Code | NONE |
| 别名 | 重组人VSIG4蛋白(C-Fc, HEK293) ;Recombinant Human VSIG4 (C-Fc, HEK293); V-set and immunoglobulin domain-containing protein 4; VSIG4; Protein Z39Ig; Z39IG; CRIg |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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