Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 质控信息
Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 生物活性
描述
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) is a 45-50 kDa macrophage-specific transmembrane glycoprotein that belongs to the B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type I g domain. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages. No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases. Human VSIG4 is 399 amino acids (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20 - 283) and a 95 aa cytoplasmic region.
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 技术信息
CAS号
N/A
分子量
30.2 KDa
SMILES Code
NONE
别名
重组人VSIG4蛋白(C-6His, HEK293)
;Recombinant Human VSIG4 (C-6His, HEK293); V-Set and Immunoglobulin Domain-Containing Protein 4; Protein Z39Ig; VSIG4; CRIg; Z39IG
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293)
|Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293)
| 重组人VSIG4蛋白(C-6His, HEK293)
| Recombinant Human VSIG4 (C-6His, HEK293)
| V-Set and Immunoglobulin Domain-Containing Protein 4
| Protein Z39Ig
| VSIG4
| CRIg
| Z39IG
| N/A
| Dendritic Cell CD Proteins
| Macrophage CD Proteins
| Stem Cell CD Proteins
| CD20 Proteins
| B Cell CD Proteins
| Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 纯度/质量文件
| Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 生物活性
| Human VSIG4 (C-6His, HEK293)/人VSIG4蛋白(C-6His, HEK293) 技术信息
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