Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293)
{[allProObj[0].p_purity_real_show]}
货号：A2926354同义名：
重组人VCAM-1蛋白(C-Fc, HEK293)
/ Recombinant Human VCAM-1 (C-Fc, HEK293); Vascular Cell Adhesion Protein 1
Recombinant Human VCAM-1 (C-Fc, HEK293)是人类来源的重组蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白为单次跨膜I型蛋白，含7个Ig样C2型结构域，是VLA-4及α4β7整合素的血管内皮配体，介导白细胞与内皮细胞的黏附与信号传导，参与炎症性肠病、动脉粥样硬化、移植排斥、感染及哮喘等病理过程的免疫细胞迁移，是潜在的抗炎治疗靶点。
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 质控信息
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 生物活性
描述
VCAM-1 is a single-pass type I membrane protein, contains 7 Ig-like C2-type domains. It is an endothelial ligand for very late antigen-4 (VLA-4) and α4?7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
101.2 kDa
SMILES Code
NONE
别名
重组人VCAM-1蛋白(C-Fc, HEK293)
;Recombinant Human VCAM-1 (C-Fc, HEK293); Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; INCAM-100; CD106; VCAM1; L1CAM
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
最近浏览的产品
Tags:
Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293)
|Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293)
| 重组人VCAM-1蛋白(C-Fc, HEK293)
| Recombinant Human VCAM-1 (C-Fc, HEK293)
| Vascular Cell Adhesion Protein 1
| V-CAM 1
| VCAM-1
| INCAM-100
| CD106
| VCAM1
| L1CAM
| N/A
| Endothelial cell CD Proteins
| Stem Cell CD Proteins
| Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 纯度/质量文件
| Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 生物活性
| Human VCAM-1 (C-Fc, HEK293)/人VCAM-1蛋白(C-Fc, HEK293) 技术信息
搜索
