货号:A2925790
同义名:
重组人UBE2K蛋白(N-GST, E.coli)
/ Recombinant Human UBE2K (N-GST, E.coli); Ubiquitin-Conjugating Enzyme E2 K
Recombinant Human UBE2K (N-GST, E.coli) 是人源泛素结合酶E2 K,在大肠杆菌中表达,带有N端GST标签。该蛋白属于E2泛素结合酶家族,主要高表达于大脑皮层和纹状体,可能通过泛素化p53促进泡沫细胞形成,并参与错误折叠蛋白的降解及阿尔茨海默病、亨廷顿病等病理过程。


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| 描述 | Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | N-GST |
| 蛋白表达区间 | Met1-Asn200 |
| 蛋白编号 | P61086 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 48.7 KDa |
| SMILES Code | NONE |
| 别名 | 重组人UBE2K蛋白(N-GST, E.coli) ;Recombinant Human UBE2K (N-GST, E.coli); Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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